骨免疫学:脊柱融合术中免疫系统的相互作用。

IF 1.7 Q2 SURGERY

International Journal of Spine Surgery Pub Date : 2023-12-27 DOI:10.14444/8556

Stephen M Bergin, Clifford L Crutcher, Carolyn Keeler, Brett Rocos, Michael M Haglund, H Michael Guo, Oren N Gottfried, William J Richardson, Khoi D Than

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引用次数: 0

摘要

脊柱融合术对手术患者的临床成功至关重要，免疫系统在其中扮演着越来越重要的角色。骨免疫学是研究免疫系统和骨骼之间相互作用的学科。炎症影响骨移植物和骨替代物的成骨、骨传导和骨诱导特性，并最终影响脊柱融合的成功。巨噬细胞已成为协调脊柱融合手术后免疫反应的重要细胞，巨噬细胞来源的细胞因子影响骨移植愈合的每个阶段。这篇综述探讨了在脊柱融合过程中调节骨稳态和愈合的细胞和分子免疫过程。

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Osteoimmunology: Interactions With the Immune System in Spinal Fusion.

Spinal fusion is important for the clinical success of patients undergoing surgery, and the immune system plays an increasingly recognized role. Osteoimmunology is the study of the interactions between the immune system and bone. Inflammation impacts the osteogenic, osteoconductive, and osteoinductive properties of bone grafts and substitutes and ultimately influences the success of spinal fusion. Macrophages have emerged as important cells for coordinating the immune response following spinal fusion surgery, and macrophage-derived cytokines impact each phase of bone graft healing. This review explores the cellular and molecular immune processes that regulate bone homeostasis and healing during spinal fusion.

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来源期刊

International Journal of Spine Surgery Medicine-Surgery

CiteScore

3.10

自引率

0.00%

发文量

162

期刊介绍： The International Journal of Spine Surgery is the official scientific journal of ISASS, the International Intradiscal Therapy Society, the Pittsburgh Spine Summit, and the Büttner-Janz Spinefoundation, and is an official partner of the Southern Neurosurgical Society. The goal of the International Journal of Spine Surgery is to promote and disseminate online the most up-to-date scientific and clinical research into innovations in motion preservation and new spinal surgery technology, including basic science, biologics, and tissue engineering. The Journal is dedicated to educating spine surgeons worldwide by reporting on the scientific basis, indications, surgical techniques, complications, outcomes, and follow-up data for promising spinal procedures.