系统性硬化症患者心房颤动的风险:一项基于全国人群的研究

IF 5.4 3区材料科学 Q2 CHEMISTRY, PHYSICAL

ACS Applied Energy Materials Pub Date : 2024-10-01 DOI:10.1093/rheumatology/kead651

Oh Chan Kwon, Kyungdo Han, Min-Chan Park

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引用次数: 0

摘要

目的:心房颤动(AF)是普通人群中最常见的心律失常，造成了巨大的经济负担、发病率和死亡率。系统性硬化症(SSc)患者房颤的发生率和风险尚不清楚。我们的目的是评估SSc患者房颤的发生率，以及SSc患者与普通人群相比发生房颤的风险。方法:以韩国国民健康保险公团数据库为数据源。从数据库中提取2010年至2017年SSc索赔数据的患者以及1:5年龄和性别匹配的对照。指数日期是2010年至2017年期间SSc索赔数据的最早日期。随访时间为指数日至2019年。采用多变量Cox比例风险模型估计SSc患者房颤的风险比(HR)和95%置信区间(CI)。结果:总的来说，包括2519例SSc患者和12595例年龄和性别匹配的对照组。在平均5.2±2.6年的随访期间，SSc患者和对照组的房颤发病率分别为每1000人年3.52例和1.68例。与对照组相比，SSc患者发生AF的风险明显更高(调整后HR = 2.095, 95% CI = 1.466-2.994)。结论:SSc患者发生房颤的风险是对照组的两倍。鉴于房颤带来的巨大经济负担、发病率和死亡率，有必要密切监测SSc患者发生房颤的情况。

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Risk of atrial fibrillation in patients with systemic sclerosis: a nationwide population-based study.

Objective: Atrial fibrillation (AF) is the most common arrhythmia in the general population, causing substantial economic burden, morbidity and mortality. The incidence rate and risk of AF in patients with SSc are unclear. We aimed to assess the incidence rate of AF in patients with SSc and the risk of incident AF in patients with SSc compared with the general population.

Methods: The Korean National Health Insurance Service database was used as the data source. Patients with claims data for SSc between 2010 and 2017 were extracted from the database along with 1:5 age- and sex-matched controls. The index date was the earliest date with claims data for SSc between 2010 and 2017. The follow-up duration was from the index date to 2019. Multivariable Cox proportional hazard models were used to estimate the hazard ratio (HR) and 95% CI for AF in patients with SSc.

Results: Overall, 2519 patients with SSc and 12 595 age- and sex-matched controls were included. Over a mean follow-up duration of 5.2 years (s.d. 2.6), the incidence rates of AF were 3.52 and 1.68 per 1000 person-years for patients with SSc and controls, respectively. Compared with controls, patients with SSc had a significantly higher risk of incident AF [adjusted HR 2.095 (95% CI 1.466, 2.994)].

Conclusion: Patients with SSc had a 2-fold higher risk of incident AF than controls. Given the significant economic burden, morbidity and mortality that AF poses, close monitoring for incident AF in patients with SSc is warranted.

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来源期刊

ACS Applied Energy Materials Materials Science-Materials Chemistry

CiteScore

10.30

自引率

6.20%

发文量

1368

期刊介绍： ACS Applied Energy Materials is an interdisciplinary journal publishing original research covering all aspects of materials, engineering, chemistry, physics and biology relevant to energy conversion and storage. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important energy applications.