Marcus ZW Tong, Julian DJ Sng, Meagan Carney, Lucy Cooper, Samuel Brown, Katie E Lineburg, Keng Yih Chew, Neve Collins, Kirsten Ignacio, Megan Airey, Lucy Burr, Briony A Joyce, Dhilshan Jayasinghe, Christopher LD McMillan, David A Muller, Anurag Adhikari, Linda A Gallo, Emily S Dorey, Helen L Barrett, Stephanie Gras, Corey Smith, Kim Good-Jacobson, Kirsty R Short
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However, the effect of an elevated BMI (≥ 25 kg m<sup>−2</sup>) on humoral immunity to SARS-CoV-2 infection and COVID-19 vaccination remains unclear.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We collected blood samples from people who recovered from SARS-CoV-2 infection approximately 3 and 13 months of post-infection (noting that these individuals were not exposed to SARS-CoV-2 or vaccinated in the interim). We also collected blood samples from people approximately 5 months of post-second dose COVID-19 vaccination (the majority of whom did not have a prior SARS-CoV-2 infection). We measured their humoral responses to SARS-CoV-2, grouping individuals based on a BMI greater or less than 25 kg m<sup>−2</sup>.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Here, we show that an increased BMI (≥ 25 kg m<sup>−2</sup>), when accounting for age and sex differences, is associated with reduced antibody responses after SARS-CoV-2 infection. At 3 months of post-infection, an elevated BMI was associated with reduced antibody titres. At 13 months of post-infection, an elevated BMI was associated with reduced antibody avidity and a reduced percentage of spike-positive B cells. In contrast, no significant association was noted between a BMI ≥ 25 kg m<sup>−2</sup> and humoral immunity to SARS-CoV-2 at 5 months of post-secondary vaccination.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Taken together, these data showed that elevated BMI is associated with an impaired humoral immune response to SARS-CoV-2 infection. 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引用次数: 0
摘要
III类肥胖(体重指数[BMI]≥40 kg m−2)显著损害对SARS-CoV-2疫苗接种的免疫应答。然而，BMI升高(≥25 kg m−2)对SARS-CoV-2感染的体液免疫和COVID-19疫苗接种的影响尚不清楚。方法我们采集了感染后约3个月和13个月从SARS-CoV-2感染中恢复的人的血液样本(注意这些人在此期间没有暴露于SARS-CoV-2或接种疫苗)。我们还收集了接种第二剂COVID-19疫苗约5个月后的人的血液样本(其中大多数人之前没有SARS-CoV-2感染)。我们测量了他们对SARS-CoV-2的体液反应，根据BMI大于或小于25 kg m -2对个体进行分组。研究结果表明，考虑到年龄和性别差异，BMI增加(≥25 kg m−2)与SARS-CoV-2感染后抗体反应降低有关。感染后3个月，BMI升高与抗体滴度降低相关。在感染后13个月，BMI升高与抗体贪婪度降低和尖峰阳性B细胞百分比降低相关。相比之下，在二次疫苗接种后5个月，BMI≥25 kg m -2与对SARS-CoV-2的体液免疫之间没有显著关联。综上所述，这些数据表明，BMI升高与对SARS-CoV-2感染的体液免疫反应受损有关。BMI≥25 kg m−2的个体感染诱导免疫功能受损，表明需要额外的动力接种疫苗，而不是依赖于感染诱导免疫。
Elevated BMI reduces the humoral response to SARS-CoV-2 infection
Objective
Class III obesity (body mass index [BMI] ≥ 40 kg m−2) significantly impairs the immune response to SARS-CoV-2 vaccination. However, the effect of an elevated BMI (≥ 25 kg m−2) on humoral immunity to SARS-CoV-2 infection and COVID-19 vaccination remains unclear.
Methods
We collected blood samples from people who recovered from SARS-CoV-2 infection approximately 3 and 13 months of post-infection (noting that these individuals were not exposed to SARS-CoV-2 or vaccinated in the interim). We also collected blood samples from people approximately 5 months of post-second dose COVID-19 vaccination (the majority of whom did not have a prior SARS-CoV-2 infection). We measured their humoral responses to SARS-CoV-2, grouping individuals based on a BMI greater or less than 25 kg m−2.
Results
Here, we show that an increased BMI (≥ 25 kg m−2), when accounting for age and sex differences, is associated with reduced antibody responses after SARS-CoV-2 infection. At 3 months of post-infection, an elevated BMI was associated with reduced antibody titres. At 13 months of post-infection, an elevated BMI was associated with reduced antibody avidity and a reduced percentage of spike-positive B cells. In contrast, no significant association was noted between a BMI ≥ 25 kg m−2 and humoral immunity to SARS-CoV-2 at 5 months of post-secondary vaccination.
Conclusions
Taken together, these data showed that elevated BMI is associated with an impaired humoral immune response to SARS-CoV-2 infection. The impairment of infection-induced immunity in individuals with a BMI ≥ 25 kg m−2 suggests an added impetus for vaccination rather than relying on infection-induced immunity.
期刊介绍：
Clinical & Translational Immunology is an open access, fully peer-reviewed journal devoted to publishing cutting-edge advances in biomedical research for scientists and physicians. The Journal covers fields including cancer biology, cardiovascular research, gene therapy, immunology, vaccine development and disease pathogenesis and therapy at the earliest phases of investigation.
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