Zhe Wang, Kaiyan Hu, Mei Wu, Liyuan Feng, Chen Liu, Fengxing Ding, Xiaohui Li, Bin Ma
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引用次数: 0
摘要
目的:本系统综述的主要目的是探讨类风湿关节炎(RA)患者冠状动脉疾病(CAD)发展的影响因素。方法:系统检索PubMed、Embase、Web of Science、万方日期、CBM、CNKI、VIP等数据库，选取相关文献。纳入研究的质量参照纽卡斯尔-渥太华量表进行评估。采用Stata16来总结meta分析的优势比、风险比、风险比和95%置信区间。结果:本分析共纳入29项研究，RA患者平均年龄50.5 ~ 81岁，女性比例44.4% ~ 92%。本荟萃分析表明，RA患者CAD风险增加与年龄、男性、吸烟、糖皮质激素、健康评估问卷评分、高脂血症、高血压、糖尿病和c反应蛋白浓度有关。结论:本系统综述揭示了RA患者继发性CAD的影响因素，其中一些可以通过戒烟、运动、药物等有效干预措施降低继发性CAD的发生风险。然而，年龄、RA严重程度和不同药物亚组对CAD风险分层的影响值得进一步研究。
Factors associated with secondary coronary artery disease in rheumatoid arthritis patients: A systematic review and meta-analysis based on observational studies.
Objective: The main objective of this systematic review was to investigate the factors influencing the development of coronary artery disease (CAD) in patients with rheumatoid arthritis (RA).
Methods: PubMed, Embase, Web of Science, Wan Fang Date, CBM, CNKI, and VIP databases were systematically searched to select the relevant literature. The quality of the incorporated studies was assessed with reference to the Newcastle-Ottawa Scale. Stata16 was adopted to summarise the odds ratios, risk ratios, hazard ratios, and 95% confidence intervals for meta-analysis.
Results: A total of 29 studies were included in this analysis, wherein the average age of RA patients was 50.5-81 years and the proportion of women was 44.4%-92%. The present meta-analysis suggested that increased CAD risk in RA patients was associated with age, male gender, smoking, glucocorticoids, Health Assessment Questionnaire scores, hyperlipidaemia, hypertension, diabetes, and C-reactive protein concentration.
Conclusion: The present systematic review revealed the influencing factors of secondary CAD in RA patients, some of which could reduce the risk of secondary CAD through effective interventions, such as smoking cessation, exercise, and medications. However, the effects of age, RA severity, and different medication subgroups on CAD risk stratification warrant further investigation.
期刊介绍：
Musculoskeletal Care is a peer-reviewed journal for all health professionals committed to the clinical delivery of high quality care for people with musculoskeletal conditions and providing knowledge to support decision making by professionals, patients and policy makers. This journal publishes papers on original research, applied research, review articles and clinical guidelines. Regular topics include patient education, psychological and social impact, patient experiences of health care, clinical up dates and the effectiveness of therapy.
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