Yiru Fu, Weiwei Ruan, Xun Sun, Fan Hu, Xiaoli Lan, Fang Liu
{"title":"局部18F-FDG PET/ mri辅助全身18F-FDG PET/CT在原发原因不明的恶性腹水中的附加价值。","authors":"Yiru Fu, Weiwei Ruan, Xun Sun, Fan Hu, Xiaoli Lan, Fang Liu","doi":"10.1186/s41824-023-00179-0","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Comparing to PET/CT, integrative PET/MRI imaging provides superior soft tissue resolution. This study aims to evaluate the added value of regional delayed <sup>18</sup>F-FDG PET/MRI-assisted whole-body <sup>18</sup>F-FDG PET/CT in diagnosing malignant ascites patients.</p><p><strong>Results: </strong>The final diagnosis included 22 patients with ovarian cancer (n = 11), peritoneal cancer (n = 3), colon cancer (n = 2), liver cancer (n = 2), pancreatic cancer (n = 2), gastric cancer (n = 1), and fallopian tube cancer (n = 1). The diagnosis of the primary tumor using whole-body PET/CT was correct in 11 cases. Regional PET/MRI-assisted whole-body PET/CT diagnosis was correct in 18 cases, including 6 more cases of ovarian cancer and 1 more case of fallopian tube cancer. Among 4 cases that were not diagnosed correctly, 1 case had the primary tumor outside of the PET/MRI scan area, 2 cases were peritoneal cancer, and 1 case was colon cancer. The diagnostic accuracy of regional PET/MRI-assisted whole-body PET/CT was higher than PET/CT alone (81.8% vs. 50.0%, κ <sup>2</sup> = 5.14, p = 0.023). The primary tumor conspicuity score of PET/MRI was higher than PET/CT (3.67 ± 0.66 vs. 2.76 ± 0.94, P < 0.01). In the same scan area, more metastases were detected in PET/MRI than in PET/CT (156 vs. 86 in total, and 7.43 ± 5.17 vs. 4.10 ± 1.92 per patient, t = 3.89, P < 0.01). Lesion-to-background ratio in PET/MRI was higher than that in PET/CT (10.76 ± 5.16 vs. 6.56 ± 3.45, t = 13.02, P < 0.01).</p><p><strong>Conclusion: </strong>Comparing to whole-body PET/CT alone, additional delayed regional PET/MRI with high soft tissue resolution is helpful in diagnosing the location of the primary tumor and identifying more metastases in patients with malignant ascites. Yet larger sample size in multicenter and prospective clinical researches is still needed.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"7 1","pages":"22"},"PeriodicalIF":1.7000,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10694118/pdf/","citationCount":"0","resultStr":"{\"title\":\"Added value of regional <sup>18</sup>F-FDG PET/MRI-assisted whole-body <sup>18</sup>F-FDG PET/CT in malignant ascites with unknown primary origin.\",\"authors\":\"Yiru Fu, Weiwei Ruan, Xun Sun, Fan Hu, Xiaoli Lan, Fang Liu\",\"doi\":\"10.1186/s41824-023-00179-0\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Comparing to PET/CT, integrative PET/MRI imaging provides superior soft tissue resolution. This study aims to evaluate the added value of regional delayed <sup>18</sup>F-FDG PET/MRI-assisted whole-body <sup>18</sup>F-FDG PET/CT in diagnosing malignant ascites patients.</p><p><strong>Results: </strong>The final diagnosis included 22 patients with ovarian cancer (n = 11), peritoneal cancer (n = 3), colon cancer (n = 2), liver cancer (n = 2), pancreatic cancer (n = 2), gastric cancer (n = 1), and fallopian tube cancer (n = 1). The diagnosis of the primary tumor using whole-body PET/CT was correct in 11 cases. Regional PET/MRI-assisted whole-body PET/CT diagnosis was correct in 18 cases, including 6 more cases of ovarian cancer and 1 more case of fallopian tube cancer. Among 4 cases that were not diagnosed correctly, 1 case had the primary tumor outside of the PET/MRI scan area, 2 cases were peritoneal cancer, and 1 case was colon cancer. The diagnostic accuracy of regional PET/MRI-assisted whole-body PET/CT was higher than PET/CT alone (81.8% vs. 50.0%, κ <sup>2</sup> = 5.14, p = 0.023). The primary tumor conspicuity score of PET/MRI was higher than PET/CT (3.67 ± 0.66 vs. 2.76 ± 0.94, P < 0.01). In the same scan area, more metastases were detected in PET/MRI than in PET/CT (156 vs. 86 in total, and 7.43 ± 5.17 vs. 4.10 ± 1.92 per patient, t = 3.89, P < 0.01). Lesion-to-background ratio in PET/MRI was higher than that in PET/CT (10.76 ± 5.16 vs. 6.56 ± 3.45, t = 13.02, P < 0.01).</p><p><strong>Conclusion: </strong>Comparing to whole-body PET/CT alone, additional delayed regional PET/MRI with high soft tissue resolution is helpful in diagnosing the location of the primary tumor and identifying more metastases in patients with malignant ascites. 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引用次数: 0
摘要
背景:与PET/CT相比，PET/MRI综合成像提供了更好的软组织分辨率。本研究旨在评价局部延迟18F-FDG PET/ mri辅助全身18F-FDG PET/CT在诊断恶性腹水患者中的附加价值。结果:最终诊断为卵巢癌(11例)、腹膜癌(3例)、结肠癌(2例)、肝癌(2例)、胰腺癌(2例)、胃癌(1例)、输卵管癌(1例)22例。全身PET/CT对原发肿瘤的诊断正确11例。局部PET/ mri辅助全身PET/CT诊断正确18例，其中卵巢癌多6例，输卵管癌多1例。在4例误诊病例中，原发肿瘤在PET/MRI扫描区外1例，腹膜癌2例，结肠癌1例。局部PET/ mri辅助全身PET/CT诊断正确率高于单独PET/CT (81.8% vs. 50.0%， κ 2 = 5.14, p = 0.023)。PET/MRI对原发肿瘤的显著性评分高于PET/CT(3.67±0.66 vs. 2.76±0.94,P)结论:与单独进行全身PET/CT相比，附加软组织分辨率较高的延迟区域性PET/MRI对恶性腹水患者原发肿瘤的位置诊断和转移灶的发现更有帮助。然而，在多中心和前瞻性临床研究中仍需要更大的样本量。
Added value of regional 18F-FDG PET/MRI-assisted whole-body 18F-FDG PET/CT in malignant ascites with unknown primary origin.
Background: Comparing to PET/CT, integrative PET/MRI imaging provides superior soft tissue resolution. This study aims to evaluate the added value of regional delayed 18F-FDG PET/MRI-assisted whole-body 18F-FDG PET/CT in diagnosing malignant ascites patients.
Results: The final diagnosis included 22 patients with ovarian cancer (n = 11), peritoneal cancer (n = 3), colon cancer (n = 2), liver cancer (n = 2), pancreatic cancer (n = 2), gastric cancer (n = 1), and fallopian tube cancer (n = 1). The diagnosis of the primary tumor using whole-body PET/CT was correct in 11 cases. Regional PET/MRI-assisted whole-body PET/CT diagnosis was correct in 18 cases, including 6 more cases of ovarian cancer and 1 more case of fallopian tube cancer. Among 4 cases that were not diagnosed correctly, 1 case had the primary tumor outside of the PET/MRI scan area, 2 cases were peritoneal cancer, and 1 case was colon cancer. The diagnostic accuracy of regional PET/MRI-assisted whole-body PET/CT was higher than PET/CT alone (81.8% vs. 50.0%, κ 2 = 5.14, p = 0.023). The primary tumor conspicuity score of PET/MRI was higher than PET/CT (3.67 ± 0.66 vs. 2.76 ± 0.94, P < 0.01). In the same scan area, more metastases were detected in PET/MRI than in PET/CT (156 vs. 86 in total, and 7.43 ± 5.17 vs. 4.10 ± 1.92 per patient, t = 3.89, P < 0.01). Lesion-to-background ratio in PET/MRI was higher than that in PET/CT (10.76 ± 5.16 vs. 6.56 ± 3.45, t = 13.02, P < 0.01).
Conclusion: Comparing to whole-body PET/CT alone, additional delayed regional PET/MRI with high soft tissue resolution is helpful in diagnosing the location of the primary tumor and identifying more metastases in patients with malignant ascites. Yet larger sample size in multicenter and prospective clinical researches is still needed.
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