{"title":"精神活性物质中毒导致青年和中年人在第一次封锁期间和之后住院。","authors":"","doi":"10.1016/j.therap.2023.10.017","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Incidence of hospitalisations related to psychoactive substance (H-PS) intoxication has been strongly decreased during the coronavirus disease 2019 (COVID-19) pandemic especially in young adult and French region of Nouvelle-Aquitaine was mostly concerned. This study aimed to describe (i) the incidence of H-PS in Bordeaux teaching hospital during and after the first 2020 lockdown in adults aged 18–29 years or 30+ then (ii) their characteristics specifically associated with the pandemic period by comparing 2020 with 2017–2019 baseline period.</p></div><div><h3>Material and methods</h3><p><span><span>This historical cohort study was conducted in adults admitted to the Bordeaux teaching hospital with main or associated diagnosis codes of intoxication with </span>benzodiazepine<span>, methadone, buprenorphine, </span></span>codeine, morphine, heroin, cocaine, ecstasy and alcohol. Data were collected locally through the discharge database. Incidence and characteristics of H-PS were described according to patients’ age, in 2020 before (01/01–16/03), during (17/03–10/05), and after the first lockdown (11/05–31/07).</p></div><div><h3>Results</h3><p>Among the 5,824 stays included over the study period, PS most involved were alcohol and benzodiazepines. Compared to baseline, the decrease in H-PS's incidence was more important in young adults (−40%; n<sub>baseline</sub> <!-->=<!--> <!-->450) in comparison to those aged 30+ (−18%; n<sub>baseline</sub> <!-->=<!--> <!-->1,101) during the pandemic period, especially during the lockdown compared to 2017 (−59%; n<sub>2017</sub> <!-->=<!--> <!-->145 vs. −35%; n<sub>2017</sub> <!-->=<!--> <!-->166) with far decrease in alcohol and ecstasy intoxications. Seriousness of hospitalisation indications was increased regardless of age during the pandemic. Particularly in young adults, the proportion of suicides attempts increased during lockdown compared to the baseline period (almost 50% vs. 29%) and the period after lockdown was associated with 1.7 more-time road accident increased and 3 more-time fights compared with pre-lockdown period.</p></div><div><h3>Discussion/conclusion</h3><p>The period following lockdown should be considered at risk H-PS due to accident. Recreational use of alcohol and ecstasy could be a target for minimize serious consequences associated to PS use in young adult.</p></div>","PeriodicalId":23147,"journal":{"name":"Therapie","volume":"79 4","pages":"Pages 419-428"},"PeriodicalIF":2.2000,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Psychoactive substance intoxication leading to general hospital admission in young and middle-aged people during and after the first lockdown\",\"authors\":\"\",\"doi\":\"10.1016/j.therap.2023.10.017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Incidence of hospitalisations related to psychoactive substance (H-PS) intoxication has been strongly decreased during the coronavirus disease 2019 (COVID-19) pandemic especially in young adult and French region of Nouvelle-Aquitaine was mostly concerned. This study aimed to describe (i) the incidence of H-PS in Bordeaux teaching hospital during and after the first 2020 lockdown in adults aged 18–29 years or 30+ then (ii) their characteristics specifically associated with the pandemic period by comparing 2020 with 2017–2019 baseline period.</p></div><div><h3>Material and methods</h3><p><span><span>This historical cohort study was conducted in adults admitted to the Bordeaux teaching hospital with main or associated diagnosis codes of intoxication with </span>benzodiazepine<span>, methadone, buprenorphine, </span></span>codeine, morphine, heroin, cocaine, ecstasy and alcohol. Data were collected locally through the discharge database. Incidence and characteristics of H-PS were described according to patients’ age, in 2020 before (01/01–16/03), during (17/03–10/05), and after the first lockdown (11/05–31/07).</p></div><div><h3>Results</h3><p>Among the 5,824 stays included over the study period, PS most involved were alcohol and benzodiazepines. Compared to baseline, the decrease in H-PS's incidence was more important in young adults (−40%; n<sub>baseline</sub> <!-->=<!--> <!-->450) in comparison to those aged 30+ (−18%; n<sub>baseline</sub> <!-->=<!--> <!-->1,101) during the pandemic period, especially during the lockdown compared to 2017 (−59%; n<sub>2017</sub> <!-->=<!--> <!-->145 vs. −35%; n<sub>2017</sub> <!-->=<!--> <!-->166) with far decrease in alcohol and ecstasy intoxications. Seriousness of hospitalisation indications was increased regardless of age during the pandemic. Particularly in young adults, the proportion of suicides attempts increased during lockdown compared to the baseline period (almost 50% vs. 29%) and the period after lockdown was associated with 1.7 more-time road accident increased and 3 more-time fights compared with pre-lockdown period.</p></div><div><h3>Discussion/conclusion</h3><p>The period following lockdown should be considered at risk H-PS due to accident. Recreational use of alcohol and ecstasy could be a target for minimize serious consequences associated to PS use in young adult.</p></div>\",\"PeriodicalId\":23147,\"journal\":{\"name\":\"Therapie\",\"volume\":\"79 4\",\"pages\":\"Pages 419-428\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapie\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040595723001865\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapie","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040595723001865","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
摘要
导语:在2019冠状病毒病(COVID-19)大流行期间，与精神活性物质(H-PS)中毒相关的住院率大幅下降，特别是在年轻人和法国新阿基坦地区最为关注。本研究旨在描述(i)波尔多教学医院在2020年第一次封锁期间和之后18-29岁或30岁以上成年人的H-PS发病率，然后(ii)通过将2020年与2017-2019年基线期进行比较，他们与大流行期具体相关的特征。材料和方法:本研究对波尔多教学医院以苯二氮卓类药物、美沙酮、丁丙诺啡、可待因、吗啡、海洛因、可卡因、摇头丸和酒精中毒为主要或相关诊断代码的成人进行了历史队列研究。数据通过出院数据库在当地收集。根据患者年龄、2020年首次封城前(01/01-16/03)、期间(17/03-10/05)和封城后(11/05-31/07)描述H-PS的发病率和特征。结果:在研究期间的5824名住院患者中，PS涉及最多的是酒精和苯二氮卓类药物。与基线相比，H-PS发病率的下降在年轻人中更为重要(-40%;Nbaseline =450)，与30岁以上的人相比(-18%;Nbaseline = 1101)，特别是与2017年相比(-59%;N2017 =145 vs. -35%;N2017 =166)，酒精和摇头丸中毒明显减少。在大流行期间，无论年龄大小，住院指征的严重程度都有所增加。特别是在年轻人中，与基准期相比，封锁期间自杀未遂的比例增加了(近50%对29%)，封锁后的时期与封锁前相比，道路交通事故增加了1.7次，打架事件增加了3次。讨论/结论:由于事故，封城后的一段时间应被视为处于H-PS风险中。娱乐性使用酒精和摇头丸可能是一个目标，以尽量减少严重后果与使用PS的年轻人。
Psychoactive substance intoxication leading to general hospital admission in young and middle-aged people during and after the first lockdown
Introduction
Incidence of hospitalisations related to psychoactive substance (H-PS) intoxication has been strongly decreased during the coronavirus disease 2019 (COVID-19) pandemic especially in young adult and French region of Nouvelle-Aquitaine was mostly concerned. This study aimed to describe (i) the incidence of H-PS in Bordeaux teaching hospital during and after the first 2020 lockdown in adults aged 18–29 years or 30+ then (ii) their characteristics specifically associated with the pandemic period by comparing 2020 with 2017–2019 baseline period.
Material and methods
This historical cohort study was conducted in adults admitted to the Bordeaux teaching hospital with main or associated diagnosis codes of intoxication with benzodiazepine, methadone, buprenorphine, codeine, morphine, heroin, cocaine, ecstasy and alcohol. Data were collected locally through the discharge database. Incidence and characteristics of H-PS were described according to patients’ age, in 2020 before (01/01–16/03), during (17/03–10/05), and after the first lockdown (11/05–31/07).
Results
Among the 5,824 stays included over the study period, PS most involved were alcohol and benzodiazepines. Compared to baseline, the decrease in H-PS's incidence was more important in young adults (−40%; nbaseline = 450) in comparison to those aged 30+ (−18%; nbaseline = 1,101) during the pandemic period, especially during the lockdown compared to 2017 (−59%; n2017 = 145 vs. −35%; n2017 = 166) with far decrease in alcohol and ecstasy intoxications. Seriousness of hospitalisation indications was increased regardless of age during the pandemic. Particularly in young adults, the proportion of suicides attempts increased during lockdown compared to the baseline period (almost 50% vs. 29%) and the period after lockdown was associated with 1.7 more-time road accident increased and 3 more-time fights compared with pre-lockdown period.
Discussion/conclusion
The period following lockdown should be considered at risk H-PS due to accident. Recreational use of alcohol and ecstasy could be a target for minimize serious consequences associated to PS use in young adult.
期刊介绍：
Thérapie is a peer-reviewed journal devoted to Clinical Pharmacology, Therapeutics, Pharmacokinetics, Pharmacovigilance, Addictovigilance, Social Pharmacology, Pharmacoepidemiology, Pharmacoeconomics and Evidence-Based-Medicine. Thérapie publishes in French or in English original articles, general reviews, letters to the editor reporting original findings, correspondence relating to articles or letters published in the Journal, short articles, editorials on up-to-date topics, Pharmacovigilance or Addictovigilance reports that follow the French "guidelines" concerning good practice in pharmacovigilance publications. The journal also publishes thematic issues on topical subject.
The journal is indexed in the main international data bases and notably in: Biosis Previews/Biological Abstracts, Embase/Excerpta Medica, Medline/Index Medicus, Science Citation Index.
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