尼日利亚伊巴丹不明原因不孕妇女血清铜、锌和硒水平:一项横断面分析研究。

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL
Adewale Ayodeji Adeniyi, Olayinka Oladunjoye Ogunbode, Ayodeji Sylvester Adeyanju, Adesina Oladokun
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引用次数: 0

摘要

背景:不孕症是影响夫妇的全球性公共卫生问题。微量金属与男性有效的生殖功能有关,但对女性的研究较少。目的:比较不明原因不孕和育龄妇女血清铜(Cu)、锌(Zn)、硒(Se)水平和铜锌比。研究对象和方法:这是一项横断面分析研究,将75名自愿患有不明原因不孕症的妇女与74名有生育能力的妇女进行比较。两组患者均在分娩后一年内就诊,均从伊巴丹大学学院医院的计划生育科招募。通过半结构化问卷获得数据,之后采集静脉血10ml。选用原子吸收分光光度法对所选微量元素进行分析。结果:不明原因不孕妇女血清Cu(93.11±16.55 μg/dL)、Zn(72.04±15.03 μg/dL)、Se(28.28±8.33 μg/dL)的平均(±SD)浓度低于对照组(P均< 0.001)。育龄妇女血清Cu/Zn比值较高,但差异无统计学意义(P < 0.62)。结论:不明原因不孕妇女血清铜、锌和硒浓度明显较低,因此含有这些微量元素的饮食或补充剂可能有助于控制这些微量元素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Serum copper, zinc and selenium levels in women with unexplained infertility in Ibadan Nigeria: A cross-sectional analytical study.

Background: Infertility is a global public health issue affecting couples. Trace metals have been implicated in effective reproductive functions in males but less studied in females.

Objective: To compare the serum levels of copper (Cu), zinc (Zn), selenium (Se) and copper/zinc ratio in women with unexplained infertility and fertile women.

Subjects and methods: This was a cross-sectional analytical study that compared 75 consenting women who had unexplained infertility with 74 fertile women that were controls. Both groups were seen within 1 year of delivery and were recruited from the family planning unit, at the University College Hospital, Ibadan. Data were obtained through a semi-structured questionnaire, after which 10 mL of venous blood was collected. Analysis of selected trace elements were done by atomic absorption spectrophotometry. IBM SPSS version 23 was utilized for data analysis and the levels of statistical significance was set at <0.05.

Results: The mean (± SD) serum concentrations of Cu (93.11 ± 16.55 μg/dL), Zn (72.04 ± 15.03 μg/dL) and Se (28.28 ± 8.33 μg/dL) amongst the women with unexplained infertility were lower when compared to the control group (all with P < 0.001). The serum Cu/Zn ratio was higher among the fertile women, though not statistically significant (P < 0.62). Age of <35 years was associated with normal serum levels of Cu (P < 0.01), while women with normal body mass index had low serum concentrations of Cu (P = 0.04), amongst the fertile group.

Conclusion: Serum copper, zinc and selenium concentrations are significantly lower in women with unexplained infertility, therefore diets or supplements containing these trace elements may be helpful in their management.

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来源期刊
Nigerian Postgraduate Medical Journal
Nigerian Postgraduate Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.90
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发文量
52
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