美国成年人全身免疫炎症指数与甲状腺功能之间的关系

IF 4.4 3区 医学 Q2 CELL BIOLOGY
Mediators of Inflammation Pub Date : 2023-11-16 eCollection Date: 2023-01-01 DOI:10.1155/2023/5831858
Xin-Yu Hu, Ying-Chao Liang, Huan-Huan Zhang, Hui-Lin Li, De-Liang Liu
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引用次数: 0

摘要

背景:全身免疫炎症指数(SII)被广泛用作疾病预后的指标。甲状腺功能已被发现与炎症密切相关。本研究的目的是分析SII与各种甲状腺功能之间的相关性。方法:本研究利用2007-2012年国家健康与营养检查调查(NHANES)的数据。采用加权单变量和多变量线性回归分析SII与甲状腺功能之间的关系。亚组分析、相互作用检验和加权限制性三次样条(RCS)回归分析也被用来检验这种相关性。结果:6875名参与者(年龄≥20岁),平均年龄46.87±0.40岁。调整后的模型显示,lnSII与FT3 (β = -0.0559, 95% CI -0.1060 ~ -0.0059,)和FT3/FT4 (β = -0.0920, 95% CI -0.1667 ~ -0.0173,)呈负相关。lnSII与TT4呈正相关(β = 0.1499, 95% CI 0.0722-0.2276,)。在亚组分析中,lnSII仍然独立影响广泛的甲状腺功能。加权RCS分析显示FT3与lnSII之间存在非线性关系。结论:SII与多种甲状腺功能有密切关系。SII可作为预测甲状腺功能障碍的指标。控制炎症活动可能是预防甲状腺功能障碍的一种保护措施。需要更多的大规模前瞻性研究来进一步探讨SII与甲状腺功能的相关性以及肥胖在其中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association between the Systemic Immune-Inflammation Index and Thyroid Function in U.S. Adults.

Background: The systemic immune-inflammation index (SII) is used as an indicator of prognosis for a wide range of diseases. Thyroid function has been found to be strongly associated with inflammation. The purpose of this investigation was to analyze the correlation between SII and various thyroid functions.

Methods: This study utilized data from the National Health and Nutrition Examination Survey (NHANES) 2007-2012. The association between SII and thyroid function was analyzed using weighted univariate and multivariate linear regression analyses. Subgroup analyses, interaction tests, and weighted restricted cubic spline (RCS) regression analyses were also employed to test this correlation.

Results: Of the 6,875 participants (age ≥ 20 years), the mean age was 46.87 ± 0.40 years. The adjusted model showed that lnSII was negatively correlated with FT3 (β = -0.0559, 95% CI -0.1060 to -0.0059,) and FT3/FT4 (β = -0.0920, 95% CI -0.1667 to -0.0173,). There was a positive correlation between lnSII and TT4 (β = 0.1499, 95% CI 0.0722-0.2276,). In subgroup analyses, lnSII still independently affected a wide range of thyroid functions. Weighted RCS analysis showed a nonlinear relationship between FT3 and lnSII.

Conclusion: Close relationships exist between SII and a variety of thyroid functions. SII can be used as an indicator to predict thyroid dysfunction. Control of inflammatory activity may be a protective measure against thyroid dysfunction. More large-scale prospective studies are necessary to further explore the correlation between SII and thyroid function and the role of obesity in this.

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来源期刊
Mediators of Inflammation
Mediators of Inflammation 医学-免疫学
CiteScore
8.70
自引率
0.00%
发文量
202
审稿时长
4 months
期刊介绍: Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.
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