可见光诱导镍催化芳基溴与腈的交叉偶联

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2023-11-30 DOI:10.1021/acs.orglett.3c03458

Jie Gao, Xian-Chen He, Yan-Ling Liu, Ke-Rong Li, Jian-Ping Guan, Hong-Bin Chen, Hao-Yue Xiang, Kai Chen* and Hua Yang*,

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引用次数: 0

摘要

本文报道了一种可见光诱导镍催化芳基溴与腈的交叉偶联反应。利用易得的腈作为羰基前体，制备了一系列结构多样的芳基酮。合成简单，温和的反应条件和酸性官能团耐受性将扩大该方案的合成用途，作为格氏/有机锂方案的一种权宜替代方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Visible-Light-Induced Nickel-Catalyzed Cross-Coupling of Aryl Bromides with Nitriles

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Visible-Light-Induced Nickel-Catalyzed Cross-Coupling of Aryl Bromides with Nitriles

Herein, a visible-light-induced nickel-catalyzed cross-coupling of aryl bromide with nitrile has been reported. By utilization of readily available nitriles as carbonyl precursors, a range of structurally diverse aryl ketones were facilely constructed. The synthetic simplicity, mild reaction conditions, and acidic functional group tolerance would broaden the synthetic utilities of this developed protocol as an expedient alternative to Grignard/organolithium protocols.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.