评估维生素D缺乏症重症儿童维生素D3负荷剂量的前瞻性试点研究。

IF 2.1 4区医学 Q3 PHARMACOLOGY & PHARMACY

Fundamental & Clinical Pharmacology Pub Date : 2023-11-27 DOI:10.1111/fcp.12973

Elizabeth W. Covington, Shaneese L. Jasper-Trotter, Robert D. Arnold, Raj Amin, Susan Egbert, Allison Chung

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引用次数: 0

摘要

背景:维生素D缺乏症在危重儿童中很常见。然而，该患者群体的最佳补充策略尚不清楚。本研究的目的是评估高剂量(10 000 IU/kg，最大剂量)的影响。40万IU)补充维生素D对儿童重症监护病房(PICU)基线维生素D缺乏症患者25-羟基维生素D3 (25[OH]D3)水平的影响方法:这是一项前瞻性的、机构审查委员会批准的试点研究，在阿拉巴马州莫比尔的南阿拉巴马大学妇女和儿童医院进行。研究样本包括入院PICU的年龄小于18岁的患者，基线25-羟基维生素D (25[OH]D)水平低于30 ng/ml。纳入的患者接受一次剂量的维生素D3口服或通过胃管(10 000 IU/kg，最大。40万iu)。结果:共筛选17例患者，其中11例纳入研究。血液分析显示，从基线到给药后12小时，25(OH)D3水平显著增加(21.6 [4.5]ng/ml vs. 46.7 [15.5] ng/ml, P。40万IU)可显著提高危重儿科患者25(OH)D3水平。

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Prospective pilot study evaluating a vitamin D3 loading dose in critically ill children with vitamin D deficiency

Background

Vitamin D deficiency is a common finding in critically ill children. However, the optimal supplementation strategy in this patient population is unknown. The objective of this study was to evaluate the effects of high-dose (10 000 IU/kg, max. 400 000 IU) vitamin D supplementation on 25-hydroxyvitamin D3 (25[OH]D3) levels in pediatric intensive care unit (PICU) patients with baseline vitamin D deficiency.

Methods

This was a prospective, institutional review board-approved pilot research study performed at the University of South Alabama Women's and Children's Hospital in Mobile, AL. The study sample consisted of patients less than 18 years old admitted to the PICU with baseline 25-hydroxyvitamin D (25[OH]D) level less than 30 ng/ml. Included patients received a one-time dose of vitamin D3 orally or via gastric tube (10 000 IU/kg, max. 400 000 IU).

Results

A total of 17 patients were screened with 11 included in the study. Blood analysis revealed a significant increase in 25(OH)D3 level from baseline to 12-h post dose (21.6 [4.5] ng/ml vs. 46.7 [15.5] ng/ml, P < 0.001). At the 12-h post-dose time point, 10/11 patients (91%) had 25(OH)D3 levels that were greater than 30 ng/ml. No adverse effects were observed.

Conclusion

Vitamin D3 supplementation at a dose of 10 000 IU/kg (max. 400 000 IU) significantly increased 25(OH)D3 levels in critically ill pediatric patients.

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来源期刊

Fundamental & Clinical Pharmacology 医学-药学

CiteScore

5.30

自引率

6.90%

发文量

111

审稿时长

6-12 weeks

期刊介绍： Fundamental & Clinical Pharmacology publishes reports describing important and novel developments in fundamental as well as clinical research relevant to drug therapy. Original articles, short communications and reviews are published on all aspects of experimental and clinical pharmacology including: Antimicrobial, Antiviral Agents Autonomic Pharmacology Cardiovascular Pharmacology Cellular Pharmacology Clinical Trials Endocrinopharmacology Gene Therapy Inflammation, Immunopharmacology Lipids, Atherosclerosis Liver and G-I Tract Pharmacology Metabolism, Pharmacokinetics Neuropharmacology Neuropsychopharmacology Oncopharmacology Pediatric Pharmacology Development Pharmacoeconomics Pharmacoepidemiology Pharmacogenetics, Pharmacogenomics Pharmacovigilance Pulmonary Pharmacology Receptors, Signal Transduction Renal Pharmacology Thrombosis and Hemostasis Toxicopharmacology Clinical research, including clinical studies and clinical trials, may cover disciplines such as pharmacokinetics, pharmacodynamics, pharmacovigilance, pharmacoepidemiology, pharmacogenomics and pharmacoeconomics. Basic research articles from fields such as physiology and molecular biology which contribute to an understanding of drug therapy are also welcomed.