David Minnikin教授纪念讲座:分枝杆菌细胞壁脂质生物标志物的时代

IF 2.8 3区医学 Q3 IMMUNOLOGY

Tuberculosis Pub Date : 2023-11-25 DOI:10.1016/j.tube.2023.102415

Oona Y-C Lee , Houdini H.T. Wu , Gurdyal S. Besra

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引用次数: 0

摘要

本文谨以此纪念大卫·欧内斯特·米尼金教授(1939-2021)。大卫是半个多世纪以来引领结核分枝杆菌细胞包膜研究领域的关键科学家之一。从分枝杆菌细胞壁异常脂质的分类、鉴定和提取，到利用它们作为敏感检测的特征脂质生物标志物，他的想法在结核病(TB)领域开辟了整个世界的可能性。此外，他对复杂模型的定义现在形成了我们对结核分枝杆菌细胞包膜的理解的一个关键里程碑，并解决了关于结核分枝杆菌进化的许多悬而未决的问题。

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Professor David Minnikin Memorial Lecture: An era of the mycobacterial cell wall lipid biomarkers

This paper is dedicated to the memory of Professor David Ernest Minnikin (1939–2021). David was one of the key scientists who pioneered the field of Mycobacterium tuberculosis cell envelope research for over half a century. From the classification, identification, and extraction of the unusual lipids of the mycobacterial cell wall, to exploiting them as characteristic lipid biomarkers for sensitive detection, his ideas enlightened a whole world of possibilities within the tuberculosis (TB) field. In addition, his definition of the intricate models now forms a key milestone in our understanding of the M. tuberculosis cell envelope and has resolved many unanswered questions on the evolution of M. tuberculosis.

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来源期刊

Tuberculosis 医学-呼吸系统

CiteScore

4.60

自引率

3.10%

发文量

审稿时长

49 days

期刊介绍： Tuberculosis is a speciality journal focusing on basic experimental research on tuberculosis, notably on bacteriological, immunological and pathogenesis aspects of the disease. The journal publishes original research and reviews on the host response and immunology of tuberculosis and the molecular biology, genetics and physiology of the organism, however discourages submissions with a meta-analytical focus (for example, articles based on searches of published articles in public electronic databases, especially where there is lack of evidence of the personal involvement of authors in the generation of such material). We do not publish Clinical Case-Studies. Areas on which submissions are welcomed include: -Clinical TrialsDiagnostics- Antimicrobial resistance- Immunology- Leprosy- Microbiology, including microbial physiology- Molecular epidemiology- Non-tuberculous Mycobacteria- Pathogenesis- Pathology- Vaccine development. This Journal does not accept case-reports. The resurgence of interest in tuberculosis has accelerated the pace of relevant research and Tuberculosis has grown with it, as the only journal dedicated to experimental biomedical research in tuberculosis.