硫酸镍、硫酸铅和亚砷酸钠单独和紫外光对培养的人淋巴细胞姐妹染色单体交换的影响。

Molecular toxicology Pub Date : 1989-04-01
R K Sahu, S P Katsifis, P L Kinney, N T Christie
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引用次数: 0

摘要

在体外用金属盐、硫酸镍、硫酸铅和亚砷酸钠处理人淋巴细胞后,研究了姐妹染色单体交换(SCE)。与未经治疗的淋巴细胞相比,所有金属盐均显著增加了SCE频率。还检查了金属处理联合紫外线(200 ergs/mm2)的SCE频率。对于铅处理与选定的紫外线剂量相结合,与单独使用紫外线或金属的SCE反应相比,观察到添加性SCE反应。对于大多数测试浓度,镍和亚砷酸盐联合紫外线处理产生的SCE响应小于添加剂。这些结果表明,在复杂混合物中存在的镍或亚砷酸盐可能会减少对混合物中通常能够产生更强SCE反应的其他化合物的SCE反应,从而导致低估化学接触的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of nickel sulfate, lead sulfate, and sodium arsenite alone and with UV light on sister chromatid exchanges in cultured human lymphocytes.

Sister chromatid exchanges (SCE) have been examined in human lymphocytes following in vitro treatments with metal salts, nickel sulfate, lead sulfate and sodium arsenite. All of the metal salts produced significant increases in the SCE frequencies over the levels for untreated lymphocytes. The SCE frequencies were also examined for metal treatments combined with ultraviolet light (200 ergs/mm2). For the lead treatments combined with the UV dose selected, an additive SCE response was observed compared to the SCE responses for UV or metal alone. The nickel and arsenite treatments combined with UV produced a less than additive SCE response for most concentrations tested. These results suggest that nickel or arsenite present in complex mixtures may reduce the SCE response to other compounds in the mixture normally capable of producing a much stronger SCE response and therefore lead to an underestimate of the effects of chemical exposure.

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