计划接受肝脏或胰腺手术的不适应患者短期运动预适应后的心脏和肌肉内适应:多核MRI研究的研究方案

IF 3.3 Q2 GASTROENTEROLOGY & HEPATOLOGY
Allard G Wijma, Heleen Driessens, Jeroen A L Jeneson, Maryska L G Janssen-Heijnen, Tineke P Willems, Joost M Klaase, Bart C Bongers
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引用次数: 0

摘要

简介:短期运动康复计划已经证明有希望的结果,在改善有氧能力不适合患者在大腹部手术之前。然而,对于心脏和骨骼肌的适应性解释短期运动康复后有氧能力的改善知之甚少。方法和分析:本研究采用前测后测设计,招募12例术前摄氧量(VO2)≤13 mL/kg/min和/或运动峰值VO2≤18 mL/kg/min的不适合患者,这些患者计划在荷兰格罗宁根大学医学中心(UMCG)接受肝胆胰手术。作为标准护理的一部分,建议不适合的患者参加以家庭为基础的运动康复计划,包括每周三次高强度间歇训练和功能锻炼,并结合营养支持,为期4周。干预前和干预后,患者将完成心肺运动测试。在此之后,研究参与者将在干预前后对股四头肌进行额外的体内运动心脏磁共振(MR)成像和磷31-MR光谱,分别评估对心脏和骨骼肌功能的影响。伦理和传播:该研究于2023年5月由UMCG医学研究伦理委员会批准(注册号NL83611.042.23, 2023年3月),并在ClinicalTrials.gov注册。这项研究的结果将提交给(国际)国家大会,并在同行评议的期刊上发表。试验注册号:NCT05772819。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cardiac and intramuscular adaptations following short-term exercise prehabilitation in unfit patients scheduled to undergo hepatic or pancreatic surgery: study protocol of a multinuclear MRI study.

Introduction: Short-term exercise prehabilitation programmes have demonstrated promising results in improving aerobic capacity of unfit patients prior to major abdominal surgery. However, little is known about the cardiac and skeletal muscle adaptations explaining the improvement in aerobic capacity following short-term exercise prehabilitation.

Methods and analysis: In this single-centre study with a pretest-post-test design, 12 unfit patients with a preoperative oxygen uptake (VO2) at the ventilatory anaerobic threshold ≤13 mL/kg/min and/or VO2 at peak exercise ≤18 mL/kg/min, who are scheduled to undergo hepatopancreatobiliary surgery at the University Medical Center Groningen (UMCG), the Netherlands, will be recruited. As part of standard care, unfit patients are advised to participate in a home-based exercise prehabilitation programme, comprising high-intensity interval training and functional exercises three times per week, combined with nutritional support, during a 4-week period. Pre-intervention and post-intervention, patients will complete a cardiopulmonary exercise test. Next to this, study participants will perform additional in-vivo exercise cardiac magnetic resonance (MR) imaging and phosphorus 31-MR spectroscopy of the quadriceps femoris muscle before and after the intervention to assess the effect on respectively cardiac and skeletal muscle function.

Ethics and dissemination: This study was approved in May 2023 by the Medical Research Ethics Committee of the UMCG (registration number NL83611.042.23, March 2023) and is registered in the ClinicalTrials.gov register. Results of this study will be submitted for presentation at (inter)national congresses and publication in peer-reviewed journals.

Trial registration number: NCT05772819.

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来源期刊
BMJ Open Gastroenterology
BMJ Open Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
5.90
自引率
3.20%
发文量
68
审稿时长
2 weeks
期刊介绍: BMJ Open Gastroenterology is an online-only, peer-reviewed, open access gastroenterology journal, dedicated to publishing high-quality medical research from all disciplines and therapeutic areas of gastroenterology. It is the open access companion journal of Gut and is co-owned by the British Society of Gastroenterology. The journal publishes all research study types, from study protocols to phase I trials to meta-analyses, including small or specialist studies. Publishing procedures are built around continuous publication, publishing research online as soon as the article is ready.
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