甲氯蝶呤对紫外线诱导红斑的抑制作用——一项随机、安慰剂对照、双盲研究。

Photo-dermatology Pub Date : 1989-04-01
T F Anderson, C Peterson, T Hamilton
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引用次数: 0

摘要

系统性皮内和局部类二十烷酸合成抑制剂已被证明可以降低强度,延迟因单次暴露于紫外线(UV)光而产生的红斑的发作。我们研究了单次和多次剂量甲氯蝶呤对单次和多次紫外光诱导的红斑的影响。30名白种人受试者服用甲氯异丙酸100 mg / d或相匹配的安慰剂5天,在2天的洗脱期后再服用另一种药物5天。在研究开始前和研究期间连续8天对红斑反应进行统计分析。单次和多次暴露数据的分析显示,与安慰剂相比,甲氯蝶呤治疗对红斑的抑制具有统计学意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Meclofenomate inhibition of UV-induced erythema--a randomized, placebo-controlled, double-blind study.

Systemic intradermal and topical inhibitors of eicosanoid synthesis have been shown to decrease the intensity delay the onset of erythema produced with a single exposure to ultraviolet (UV) light. We studied the effect of single and multiple doses of meclofenomate on erythema induced by single and multiple doses of UV light. Thirty Caucasian subjects took either meclofenomate 100 mg t.i.d. or matching placebo for 5 days, crossing over to the alternative for 5 more days after a 2-day washout period. A statistical analysis was made of erythema response immediately prior to the study and then on 8 successive days during the study. Analysis of single and multiple exposure data revealed a statistically significant inhibition of erythema from meclofenomate therapy as compared with placebo.

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