Puja Parekh, Patrick Begley, Maryam Jessop, Mark Aplin, Elena Missir, Helena McMeekin, Gosia Raczek, Nitasha Singh, Sabina Dizdarevic
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Relative semi-quantitative specific binding ratios (SBRs) from Chang attenuated SPECT were obtained from GE DaTQUANT. Absolute normalised concentration (NC) was calculated from attenuation/scatter corrected SPECT-CT images, using an adapted version of the EARL Ltd (European Association of Nuclear Medicine (EANM) Research 4 Life) template. Scans were subdivided into either degenerative parkinsonism (abnormal = 49), borderline (n = 14) or scan without evidence of dopaminergic deficit (SWEDD = 11) using visual assessment and SBR values by two nuclear medicine consultants.</p><p><strong>Results: </strong>SBRs did not correlate with BMI. However, NC values correlated negatively in the entire cohort, with the strongest correlation in the frontal (r = - 0.649. p = 0.000), occipital (r = - 0.555, p = 0.000) regions and pons (r = - 0.555, p = 0.000). In the abnormal (n = 49) and SWEDD group (n = 11), NC of the frontal region was the most correlated with BMI (r = - 0.570, p = 0.000; r = - 0.813, p = 0.002, respectively). In the borderline group (n = 14), the left posterior putamen displayed the strongest correlation (r = - 0.765, p = 0.001).</p><p><strong>Conclusion: </strong>Absolute NC values demonstrate a strong inverse correlation with BMI, strongest in the extrastriatal regions. Due to the predominately non-overlapping distribution of DaT and SERT, this study suggests greater involvement of SERT in obesity with possible interplay with DA transmission.</p>","PeriodicalId":36160,"journal":{"name":"European Journal of Hybrid Imaging","volume":"7 1","pages":"21"},"PeriodicalIF":1.7000,"publicationDate":"2023-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10657921/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between body mass index (BMI) and [<sup>123</sup>I]Ioflupane (DaTSCAN) availabilities in patients with parkinsonism using single-photon emission computed tomography-computed tomography (SPECT-CT).\",\"authors\":\"Puja Parekh, Patrick Begley, Maryam Jessop, Mark Aplin, Elena Missir, Helena McMeekin, Gosia Raczek, Nitasha Singh, Sabina Dizdarevic\",\"doi\":\"10.1186/s41824-023-00181-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>[<sup>123</sup>I]Ioflupane (DaTSCAN) has a high binding affinity to the dopamine (DA) transporter (DaT) and tenfold less affinity to serotonin (5-HT) transporter (SERT). 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Scans were subdivided into either degenerative parkinsonism (abnormal = 49), borderline (n = 14) or scan without evidence of dopaminergic deficit (SWEDD = 11) using visual assessment and SBR values by two nuclear medicine consultants.</p><p><strong>Results: </strong>SBRs did not correlate with BMI. However, NC values correlated negatively in the entire cohort, with the strongest correlation in the frontal (r = - 0.649. p = 0.000), occipital (r = - 0.555, p = 0.000) regions and pons (r = - 0.555, p = 0.000). In the abnormal (n = 49) and SWEDD group (n = 11), NC of the frontal region was the most correlated with BMI (r = - 0.570, p = 0.000; r = - 0.813, p = 0.002, respectively). In the borderline group (n = 14), the left posterior putamen displayed the strongest correlation (r = - 0.765, p = 0.001).</p><p><strong>Conclusion: </strong>Absolute NC values demonstrate a strong inverse correlation with BMI, strongest in the extrastriatal regions. 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引用次数: 0
摘要
目的:[123I]碘氟烷(DaTSCAN)对多巴胺(DA)转运体(DaT)具有高结合亲和力，而对血清素(5-羟色胺(SERT))转运体(SERT)的亲和力低10倍。这两种神经递质都被认为有助于体重调节。本研究评估了身体质量指数(BMI)与大脑中DaTSCAN可用性之间的关系。方法:对74例连续接受DaTSCAN单光子发射计算机断层扫描(SPECT-CT)的患者进行扫描，在几个感兴趣的体积(voi)中获得半定量和绝对定量数据。从GE DaTQUANT获得Chang衰减SPECT的相对半定量特异性结合比(sbr)。绝对归一化浓度(NC)由衰减/散射校正的SPECT-CT图像计算，使用EARL Ltd(欧洲核医学协会(EANM)研究4生命)模板的改编版本。两名核医学顾问根据视觉评估和SBR值将扫描结果细分为退行性帕金森(异常= 49)、边缘性帕金森(n = 14)或无多巴胺能缺陷证据的扫描(SWEDD = 11)。结果:sbr与BMI无相关性。然而，NC值在整个队列中呈负相关，其中前额叶相关性最强(r = - 0.649)。p = 0.000),枕(r = - 0.555, p = 0.000)地区和脑桥(r = - 0.555, p = 0.000)。在异常组(n = 49)和SWEDD组(n = 11)中，额叶区NC与BMI的相关性最高(r = - 0.570, p = 0.000;R = - 0.813, p = 0.002)。在边缘组(n = 14)中，左侧后壳核的相关性最强(r = - 0.765, p = 0.001)。结论:绝对NC值与BMI呈强烈的负相关，在肠外区域最强。由于DaT和SERT的分布主要是不重叠的，本研究表明SERT在肥胖中有更大的参与，可能与DA的传播相互作用。
Association between body mass index (BMI) and [123I]Ioflupane (DaTSCAN) availabilities in patients with parkinsonism using single-photon emission computed tomography-computed tomography (SPECT-CT).
Aim: [123I]Ioflupane (DaTSCAN) has a high binding affinity to the dopamine (DA) transporter (DaT) and tenfold less affinity to serotonin (5-HT) transporter (SERT). Both neurotransmitters are considered to contribute to body weight regulation. This study assesses the association between body mass index (BMI) and DaTSCAN availability in brain.
Method: Scans from 74 consecutive patients who had undergone DaTSCAN single-photon emission computed tomography-computed tomography (SPECT-CT) were used to obtain semi- and absolute quantitative data in several volumes of interest (VOIs). Relative semi-quantitative specific binding ratios (SBRs) from Chang attenuated SPECT were obtained from GE DaTQUANT. Absolute normalised concentration (NC) was calculated from attenuation/scatter corrected SPECT-CT images, using an adapted version of the EARL Ltd (European Association of Nuclear Medicine (EANM) Research 4 Life) template. Scans were subdivided into either degenerative parkinsonism (abnormal = 49), borderline (n = 14) or scan without evidence of dopaminergic deficit (SWEDD = 11) using visual assessment and SBR values by two nuclear medicine consultants.
Results: SBRs did not correlate with BMI. However, NC values correlated negatively in the entire cohort, with the strongest correlation in the frontal (r = - 0.649. p = 0.000), occipital (r = - 0.555, p = 0.000) regions and pons (r = - 0.555, p = 0.000). In the abnormal (n = 49) and SWEDD group (n = 11), NC of the frontal region was the most correlated with BMI (r = - 0.570, p = 0.000; r = - 0.813, p = 0.002, respectively). In the borderline group (n = 14), the left posterior putamen displayed the strongest correlation (r = - 0.765, p = 0.001).
Conclusion: Absolute NC values demonstrate a strong inverse correlation with BMI, strongest in the extrastriatal regions. Due to the predominately non-overlapping distribution of DaT and SERT, this study suggests greater involvement of SERT in obesity with possible interplay with DA transmission.
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