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Cover: In Wolfe et al. (https://doi.org/10.1002/cpps.96), Representative two phases of the isothermal detergent desorption of membrane proteins. (A) The initial phase is detergent predesolvation. (B) The follow-up, time-dependent phase is detergent desolvation. Predesolvation results from the dissociation of a relatively small number of detergent monomers from membrane proteins. This process is accompanied by a relatively small and slow change in the FP anisotropy with respect to the initial value, rmax. The second phase depicts a large and fast alteration in the FP anisotropy, as it is representative of the loss of many detergent monomers from membrane proteins. This major change in the average molecular mass of proteomicelles is reflected in a drastic alteration of the FP anisotropy, and occurs in a single-exponential fashion (right-hand panels). The kinetic rates of both predesolvation and desolvation phases are dependent on the final detergent concentration (Wolfe et al., 2018a). For example, the kinetic rates are greater for lower detergent concentrations in the protein sample. Reprinted with permission from reference Wolfe et al. (2018b). Copyright 2018, American Chemical Society.