T I Hwang, T F Lue, C R Yang, C L Chang, C H Chang, H C Wu
{"title":"海绵内注射罂粟碱与前列腺素E1对阴茎血管影响的比较。","authors":"T I Hwang, T F Lue, C R Yang, C L Chang, C H Chang, H C Wu","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>An intracavernous injection with papaverine or prostaglandin E1 (PGE1) combined with duplex ultrasonography is an objective technique to conduct a penile blood flow study (PBFS). Three hundred patients with impotence underwent papaverine (9-60 mg) induced PBFS at the University of California School of Medicine, San Francisco (UCSF), U.S.A. and another 80 patients with impotence received PGE1-induced (20 micrograms) PBFS at Veterans General Hospital-Taichung (VGH-TC), R.O.C. Preliminary evaluation of age, duration of disease and pre-injection diameter of cavernous arteries disclosed no significant difference in these 2 series. It was interesting to find that almost all parameters of vascular response to pavaverine vs PGE1 differed significantly, such as onset of response (6.5 +/- 6.5 vs 11.7 +/- 6.4 min, slower in the PGE1 group, p less than 0.001); post-injection diameter of cavernous arteries (right: 0.73 +/- 0.20 vs 0.79 +/- 0.18 mm, p = 0.03; left: 0.74 +/- 0.20 vs 0.82 +/- 0.21 mm, p = 0.005); diametral increment of cavernous arteries (right: 0.23 +/- 0.17 vs 0.33 +/- 0.17 mm, p less than 0.001; left: 0.24 +/- 0.17 vs 0.36 +/- 0.19 mm, p less than 0.001) and peak velocity (right: 27.5 +/- 16.1 vs 42.0 +/- 20.1 cm/sec, p less than 0.001; left: 28.9 +/- 15.9 vs 39.7 +/- 17.9 cm/sec, p less than 0.001). The side effects, primarily injection pain (23.8%, 19/80) in the PGE1 group and dizziness (3.0%, 9/300) in the papaverine group, were minor in these 2 series. Prolonged erection was not encountered in either series; however, immediate treatment was performed if a papaverine-induced erection lasted over 60 minutes.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":22189,"journal":{"name":"Taiwan yi xue hui za zhi. Journal of the Formosan Medical Association","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1989-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Comparison of penile vascular effect induced by intracavernous injection of papaverine and prostaglandin E1.\",\"authors\":\"T I Hwang, T F Lue, C R Yang, C L Chang, C H Chang, H C Wu\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>An intracavernous injection with papaverine or prostaglandin E1 (PGE1) combined with duplex ultrasonography is an objective technique to conduct a penile blood flow study (PBFS). 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It was interesting to find that almost all parameters of vascular response to pavaverine vs PGE1 differed significantly, such as onset of response (6.5 +/- 6.5 vs 11.7 +/- 6.4 min, slower in the PGE1 group, p less than 0.001); post-injection diameter of cavernous arteries (right: 0.73 +/- 0.20 vs 0.79 +/- 0.18 mm, p = 0.03; left: 0.74 +/- 0.20 vs 0.82 +/- 0.21 mm, p = 0.005); diametral increment of cavernous arteries (right: 0.23 +/- 0.17 vs 0.33 +/- 0.17 mm, p less than 0.001; left: 0.24 +/- 0.17 vs 0.36 +/- 0.19 mm, p less than 0.001) and peak velocity (right: 27.5 +/- 16.1 vs 42.0 +/- 20.1 cm/sec, p less than 0.001; left: 28.9 +/- 15.9 vs 39.7 +/- 17.9 cm/sec, p less than 0.001). The side effects, primarily injection pain (23.8%, 19/80) in the PGE1 group and dizziness (3.0%, 9/300) in the papaverine group, were minor in these 2 series. 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引用次数: 0
摘要
海绵内注射罂粟碱或前列腺素E1 (PGE1)结合双工超声检查是一种进行阴茎血流研究(PBFS)的客观技术。300例阳痿患者在美国加州大学旧金山分校(UCSF)接受了papaverine (9- 60mg)诱导的PBFS,另外80例阳痿患者在台湾退伍军人总医院(VGH-TC)接受了pge1(20微克)诱导的PBFS。两组患者的年龄、病程和注射前海绵状动脉直径的初步评估显示,两组患者无显著差异。有趣的是,我们发现pavaverine与PGE1的血管反应的几乎所有参数都有显著差异,例如反应开始时间(6.5 +/- 6.5 vs 11.7 +/- 6.4 min, PGE1组较慢,p < 0.001);海绵状动脉注射后直径(右:0.73 +/- 0.20 vs 0.79 +/- 0.18 mm, p = 0.03;左:0.74 + / - 0.20 vs 0.82 + / - 0.21毫米,p = 0.005);海绵动脉直径增加(右:0.23 +/- 0.17 vs 0.33 +/- 0.17 mm, p < 0.001;左:0.24 +/- 0.17 vs 0.36 +/- 0.19 mm, p小于0.001)和峰值速度(右:27.5 +/- 16.1 vs 42.0 +/- 20.1 cm/秒,p小于0.001;左:28.9 +/- 15.9 vs 39.7 +/- 17.9 cm/秒,p < 0.001)。在这两个系列中,PGE1组的主要副作用是注射疼痛(23.8%,19/80),罂粟碱组的主要副作用是头晕(3.0%,9/300)。两组均未出现长时间勃起;然而,如果罂粟碱引起的勃起持续超过60分钟,则立即进行治疗。(摘要删节250字)
Comparison of penile vascular effect induced by intracavernous injection of papaverine and prostaglandin E1.
An intracavernous injection with papaverine or prostaglandin E1 (PGE1) combined with duplex ultrasonography is an objective technique to conduct a penile blood flow study (PBFS). Three hundred patients with impotence underwent papaverine (9-60 mg) induced PBFS at the University of California School of Medicine, San Francisco (UCSF), U.S.A. and another 80 patients with impotence received PGE1-induced (20 micrograms) PBFS at Veterans General Hospital-Taichung (VGH-TC), R.O.C. Preliminary evaluation of age, duration of disease and pre-injection diameter of cavernous arteries disclosed no significant difference in these 2 series. It was interesting to find that almost all parameters of vascular response to pavaverine vs PGE1 differed significantly, such as onset of response (6.5 +/- 6.5 vs 11.7 +/- 6.4 min, slower in the PGE1 group, p less than 0.001); post-injection diameter of cavernous arteries (right: 0.73 +/- 0.20 vs 0.79 +/- 0.18 mm, p = 0.03; left: 0.74 +/- 0.20 vs 0.82 +/- 0.21 mm, p = 0.005); diametral increment of cavernous arteries (right: 0.23 +/- 0.17 vs 0.33 +/- 0.17 mm, p less than 0.001; left: 0.24 +/- 0.17 vs 0.36 +/- 0.19 mm, p less than 0.001) and peak velocity (right: 27.5 +/- 16.1 vs 42.0 +/- 20.1 cm/sec, p less than 0.001; left: 28.9 +/- 15.9 vs 39.7 +/- 17.9 cm/sec, p less than 0.001). The side effects, primarily injection pain (23.8%, 19/80) in the PGE1 group and dizziness (3.0%, 9/300) in the papaverine group, were minor in these 2 series. Prolonged erection was not encountered in either series; however, immediate treatment was performed if a papaverine-induced erection lasted over 60 minutes.(ABSTRACT TRUNCATED AT 250 WORDS)