{"title":"综述文章:胃肠道癌症的发展是否有一个共同的原则?干细胞在癌症起源中的作用","authors":"N. A. WRIGHT","doi":"10.1111/j.1746-6342.2006.00023.x","DOIUrl":null,"url":null,"abstract":"<div>\n \n <section>\n \n <h3> Summary</h3>\n </section>\n \n <section>\n \n <h3> Background</h3>\n \n <p>Accumulating evidence, outlined in this review, at last provides some elucidation of the orgin of gastrointestinal epithelial tumours.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>New techniques, such as following the process of crypt or gastric gland purification following mutation in genes encoded by the mitochondrial genome, have shown that mutations spead within the proliferative unit, either gastric gland or intestinal crypt, by clonal purification or monoclonal conversion. Spreading otside the crypt or gland then takes place by fission.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Future research should focus on the mecanisim by which mutated stem cells colonize crypts, and on the mechanisms of crypt fission itself.</p>\n </section>\n </div>","PeriodicalId":50822,"journal":{"name":"Alimentary Pharmacology & Therapeutics Symposium Series","volume":"2 1","pages":"31-40"},"PeriodicalIF":0.0000,"publicationDate":"2006-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/j.1746-6342.2006.00023.x","citationCount":"0","resultStr":"{\"title\":\"Review article: is there a common principle in the development of gastrointestinal cancers? Stem cells in the origin of cancer\",\"authors\":\"N. A. WRIGHT\",\"doi\":\"10.1111/j.1746-6342.2006.00023.x\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <section>\\n \\n <h3> Summary</h3>\\n </section>\\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Accumulating evidence, outlined in this review, at last provides some elucidation of the orgin of gastrointestinal epithelial tumours.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>New techniques, such as following the process of crypt or gastric gland purification following mutation in genes encoded by the mitochondrial genome, have shown that mutations spead within the proliferative unit, either gastric gland or intestinal crypt, by clonal purification or monoclonal conversion. Spreading otside the crypt or gland then takes place by fission.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Future research should focus on the mecanisim by which mutated stem cells colonize crypts, and on the mechanisms of crypt fission itself.</p>\\n </section>\\n </div>\",\"PeriodicalId\":50822,\"journal\":{\"name\":\"Alimentary Pharmacology & Therapeutics Symposium Series\",\"volume\":\"2 1\",\"pages\":\"31-40\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2006-06-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1111/j.1746-6342.2006.00023.x\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alimentary Pharmacology & Therapeutics Symposium Series\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/j.1746-6342.2006.00023.x\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alimentary Pharmacology & Therapeutics Symposium Series","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/j.1746-6342.2006.00023.x","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Review article: is there a common principle in the development of gastrointestinal cancers? Stem cells in the origin of cancer
Summary
Background
Accumulating evidence, outlined in this review, at last provides some elucidation of the orgin of gastrointestinal epithelial tumours.
Methods
New techniques, such as following the process of crypt or gastric gland purification following mutation in genes encoded by the mitochondrial genome, have shown that mutations spead within the proliferative unit, either gastric gland or intestinal crypt, by clonal purification or monoclonal conversion. Spreading otside the crypt or gland then takes place by fission.
Results
Future research should focus on the mecanisim by which mutated stem cells colonize crypts, and on the mechanisms of crypt fission itself.
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