咪唑[2,1-b]-喹唑啉类药物抑制磷酸二酯酶活性的QSAR研究:活性位点分析。

Drug design and delivery Pub Date : 1989-12-01
Y S Prabhakar
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引用次数: 0

摘要

已发表的7-取代-1,2,3,5-四氢-2-氧咪唑[2,1-b]喹唑啉的c-AMP磷酸二酯酶抑制活性被用于QSAR研究,以分析c-AMP PDE (IV型)活性位点的拟议模型。基于涉及疏水参数和活性的回归方程,在二级结合区G中确定了额外的子位点G1和G2,并讨论了这些子位点的空间疏水耐受性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
QSAR study of phosphodiesterase inhibitory activity of imidazo[2,1-b]-quinazolines: active site analysis.

Published c-AMP phosphodiesterase inhibitory activities of 7-substituted-1,2,3,5-tetrahydro-2-oxoimidazo[2,1-b]quinazolines are used in a QSAR study to analyse a proposed model of the c-AMP PDE (type IV) active site. Based on the regression equations involving hydrophobic parameters and activities, additional subsites G1 and G2 are identified in the secondary binding region G, and steric hydrophobic tolerance at these subsites is discussed.

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