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引用次数: 0
摘要
n -乙基亚硝基脲诱导大鼠脑瘤。利用Southern blot分析，鉴定了N-ras基因限制性内切片段长度多态性。比较研究表明，DMN诱导的肾和肝肿瘤DNA中未出现新的限制性内切位点。数据表明，发生的突变可能是特定于“目标”细胞或致癌物结构的。
N-ras mutation in chemically induced rat brain tumour.
Rat brain tumour was induced by treatment with N-ethyl-nitrosourea. Using Southern blot analysis, restriction fragment length polymorphism of N-ras gene was identified. Comparative studies showed that new restriction site did not occur in the DNA of DMN induced renal and liver tumours. The data suggest that the mutation occurring may be specific to the "target" cell or to the structure of carcinogens.
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