Danielle Bivanco-Lima , Itamar de Souza Santos , Ana Maria Cortez Vannucchi , Manoel Carlos Sampaio de Almeida Ribeiro
{"title":"抑郁症患者的心血管风险","authors":"Danielle Bivanco-Lima , Itamar de Souza Santos , Ana Maria Cortez Vannucchi , Manoel Carlos Sampaio de Almeida Ribeiro","doi":"10.1016/S2255-4823(13)70473-9","DOIUrl":null,"url":null,"abstract":"<div><p>Depression and cardiovascular diseases (CVD) are both common illnesses. Several studies demonstrated that depressed individuals have higher mortality compared to age- and gender-matched population, with an excess of cardiovascular deaths. There is a bidirectional association between depression and CVD. Several factors can interact and influence this relationship: poverty and social inequality, reduced accessibility to health care, biological alterations (as reduced heart rate variability, endothelial dysfunction, increased inflam-mation and platelet function, and hyperactivity of hypothalamic-pituitary-adrenal axis), side effects of psychiatric medication, lower adherence to medical treatments, and higher frequency of cardiovascularrisk factors (higher tobacco use, physical inactivity, obesity, dia-betes mellitus). This article aims to update the current evidence of the possible mechanisms involved in the association between depression and CVD.</p></div>","PeriodicalId":101100,"journal":{"name":"Revista da Associa??o Médica Brasileira (English Edition)","volume":"59 3","pages":"Pages 298-304"},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S2255-4823(13)70473-9","citationCount":"0","resultStr":"{\"title\":\"Cardiovascular risk in individuals with depression\",\"authors\":\"Danielle Bivanco-Lima , Itamar de Souza Santos , Ana Maria Cortez Vannucchi , Manoel Carlos Sampaio de Almeida Ribeiro\",\"doi\":\"10.1016/S2255-4823(13)70473-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Depression and cardiovascular diseases (CVD) are both common illnesses. Several studies demonstrated that depressed individuals have higher mortality compared to age- and gender-matched population, with an excess of cardiovascular deaths. There is a bidirectional association between depression and CVD. Several factors can interact and influence this relationship: poverty and social inequality, reduced accessibility to health care, biological alterations (as reduced heart rate variability, endothelial dysfunction, increased inflam-mation and platelet function, and hyperactivity of hypothalamic-pituitary-adrenal axis), side effects of psychiatric medication, lower adherence to medical treatments, and higher frequency of cardiovascularrisk factors (higher tobacco use, physical inactivity, obesity, dia-betes mellitus). This article aims to update the current evidence of the possible mechanisms involved in the association between depression and CVD.</p></div>\",\"PeriodicalId\":101100,\"journal\":{\"name\":\"Revista da Associa??o Médica Brasileira (English Edition)\",\"volume\":\"59 3\",\"pages\":\"Pages 298-304\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2013-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/S2255-4823(13)70473-9\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista da Associa??o Médica Brasileira (English Edition)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2255482313704739\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista da Associa??o Médica Brasileira (English Edition)","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2255482313704739","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Cardiovascular risk in individuals with depression
Depression and cardiovascular diseases (CVD) are both common illnesses. Several studies demonstrated that depressed individuals have higher mortality compared to age- and gender-matched population, with an excess of cardiovascular deaths. There is a bidirectional association between depression and CVD. Several factors can interact and influence this relationship: poverty and social inequality, reduced accessibility to health care, biological alterations (as reduced heart rate variability, endothelial dysfunction, increased inflam-mation and platelet function, and hyperactivity of hypothalamic-pituitary-adrenal axis), side effects of psychiatric medication, lower adherence to medical treatments, and higher frequency of cardiovascularrisk factors (higher tobacco use, physical inactivity, obesity, dia-betes mellitus). This article aims to update the current evidence of the possible mechanisms involved in the association between depression and CVD.