[γ干扰素对人类和小鼠不同类型细胞的生物活性]。

Giornale di batteriologia, virologia ed immunologia Pub Date : 1989-01-01

M Zucca, M Fiscella, G Gribaudo, T Musso, G Cavallo, S Landolfo

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引用次数: 0

摘要

干扰素(IFN γ)和IFN α / β对正常T淋巴细胞和B淋巴细胞以及各种T和非T人类和小鼠细胞系的影响已被研究。与IFN α / β不同，IFN γ不促进T细胞的抗病毒状态。在生化水平上，通过发现IFN γ在T细胞中不诱导2'，5'寡聚腺苷酸合成酶活性，证实了抗病毒活性的缺乏。

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[Biological activity of gamma interferon on various cell types in human and murine systems].

The effects of interferon (IFN gamma) and of IFN alpha/beta on normal T and B lymphocytes and various T and non-T human and murine cell lines have been investigated. IFN gamma, unlike IFN alpha/beta, did not promote the antiviral state in T cells. The lack of antiviral activity was confirmed at the biochemical level by the finding that 2',5' oligoadenylate synthetase activity is not induced in T cells by IFN gamma only.

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来源期刊

Giornale di batteriologia, virologia ed immunologia

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