Effect of several resin monomers on water insoluble glucan formation by glucosyltransferase of Streptococcus sobrinus.

The cause or mechanism by which more plaque tend to accumulate on composite resins than on any other restorative materials has yet to be sufficiently explained. The purpose of this study was to investigate a possible mechanism by clarifying the effects of several monomers on the glucosyltransferase activity from Streptococcus sobrinus. The following results were obtained. In the individual resin monomers, di-, tri- and tetra-ethylene glycol dimethacrylate (2G, 3G and 4G), Bis-GMA and UDMA showed a stimulatory tendency of water insoluble glucan (WIG) formation. However, ethylene glycol dimethacrylate (IG), polyethylene glycol dimethacrylate (9G and 14G), and MMA diminished the synthesis of water soluble glucan as the concentration of monomers was increased. In addition, the eluate from experimental resin consisted of IG and Bis-GMA decreased the production of WIG when compared to that from 3G and Bis-GMA based resin. These results indicated that it was possible to develop a composite resin which inhibits plaque accumulation by using some antienzymatic monomers.