[静脉和粘膜下注射局部麻醉和血管收缩剂后的动脉压变化]。

Odontostomatologike proodos Pub Date : 1989-08-01
A Tsirlis, D Iakovidis
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引用次数: 0

摘要

本文研究了白仓鼠静脉注射和粘膜下注射定量局麻溶液(0.05 ml)后血压(收缩压、舒张压和平均压)变化的控制、登记和统计评价。采用2%利多卡因配肾上腺素1/ 80000,3%利多卡因配去甲肾上腺素1/ 25000。静脉注射三种局麻溶液均引起动脉压参数升高,差异均有统计学意义(P < 0.01)。粘膜下注射2%利多卡因与1/8万肾上腺素的溶液和2%利多卡因与1/8万去甲肾上腺素的溶液均未引起值得一提的动脉压变化。相反,粘膜下注射利多卡因3%溶液加去甲肾上腺素1/ 25000导致动脉压升高,差异有统计学意义(P < 0.05)。研究结果得出以下结论:1)血管内注射含肾上腺素或去甲肾上腺素的局部麻醉剂对循环系统有直接的负面影响,这一事实使得在任何全身麻醉之前都有必要进行呼吸试验。2)粘膜下注射含肾上腺素或去甲肾上腺素1/8万的利多卡因溶液对心血管的毒性是无害的,3)含去甲肾上腺素1/2万5千的3%利多卡因溶液在粘膜下注射后能够产生显著的动脉压升高。1/ 25000去甲肾上腺素浓度的麻醉溶液不应使用,但必须考虑到它们对心血管疾病患者极为危险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Arterial pressure variation following an intravenous and submucous injection of local anaesthetic solutions with vasoconstrictor].

This paper deals with the control, registration and statistical evaluation of blood pressure variations (systolic, diastolic and average) after an i.v. and submucous injection of fixed quantity local anaesthetic solutions (0.05 ml) in white hamsters. The solutions used were: lidocaine 2% with adrenaline 1/80,000, lidocaine 3% with noradrenaline 1/25,000. The intravenous injection of all three local anaesthetic solutions has caused an increase of the arterial pressure parameters which was statistically significant (P less than 0.01). The submucous injection of lidocaine 2% solution with adrenaline 1/80,000 and lidocaine 2% with noradrenaline 1/80,000 has not caused mentionworthy arterial pressure variations. On the contrary, the submucous injection of lidocaine 3% solution with noradrenaline 1/25,000 has led to an increase of the arterial pressure which is statistically important (P less than 0.05). The research results have led to the following conclusions: 1) Intravascular injection of local anaesthetics with adrenaline or noradrenaline has immediate negative consequences on the circulatory system, a fact which renders necessary a test respiration prior to any stem anaesthesia. 2) The submucous injection of lidocaine solutions with adrenaline or noradrenaline 1/80,000 may be described as harmless with respect to cardiovascular toxicity, and 3) The 3% lidocaine solution with noradrenaline 1/25,000 has proved to be capable of producing significant increase of the arterial pressure following a submucous injection. Anaesthetic solutions with 1/25,000 noradrenaline concentration should not be used, while they must be considered as extremely hazardous for patients with cardiovascular problems.

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