{"title":"类固醇诱导的昆虫肽能神经元递质可塑性","authors":"N.J. Tublitz","doi":"10.1016/0742-8413(93)90186-O","DOIUrl":null,"url":null,"abstract":"<div><p>1. Transmitter plasticity, the ability to alter transmitter expression, has been demonstrated in a wide range of neurons in the vertebrates and invertebrates.</p><p>2. One preparation where this issue has been investigated in detail is a set of four neurosecretory neurons in the tobacco hawkmoth <em>Manduca sexta</em>.</p><p>3. These neurons undergo a transmitter switch during the transition from caterpillar to moth.</p><p>4. In larvae these neurons, known as the lateral neurosecretory cells (LNCs), express CAP<sub>2</sub>, a myomodulatory neuropeptide involved in the neuroregulation of the activity of visceral muscles.</p><p>5. By the adult moth stage, however, the LNCs are no longer producing CAP<sub>2</sub> and instead are expressing a different peptide, bursicon, which is involved in tanning of the cuticle at adult emergence.</p><p>6. Here I review the evidence for this transmitter switch and discuss its regulation by steroids.</p></div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"105 2","pages":"Pages 147-154"},"PeriodicalIF":0.0000,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90186-O","citationCount":"9","resultStr":"{\"title\":\"Steroid-induced transmitter plasticity in insect peptidergic neurons\",\"authors\":\"N.J. Tublitz\",\"doi\":\"10.1016/0742-8413(93)90186-O\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>1. Transmitter plasticity, the ability to alter transmitter expression, has been demonstrated in a wide range of neurons in the vertebrates and invertebrates.</p><p>2. One preparation where this issue has been investigated in detail is a set of four neurosecretory neurons in the tobacco hawkmoth <em>Manduca sexta</em>.</p><p>3. These neurons undergo a transmitter switch during the transition from caterpillar to moth.</p><p>4. In larvae these neurons, known as the lateral neurosecretory cells (LNCs), express CAP<sub>2</sub>, a myomodulatory neuropeptide involved in the neuroregulation of the activity of visceral muscles.</p><p>5. By the adult moth stage, however, the LNCs are no longer producing CAP<sub>2</sub> and instead are expressing a different peptide, bursicon, which is involved in tanning of the cuticle at adult emergence.</p><p>6. Here I review the evidence for this transmitter switch and discuss its regulation by steroids.</p></div>\",\"PeriodicalId\":72650,\"journal\":{\"name\":\"Comparative biochemistry and physiology. C: Comparative pharmacology\",\"volume\":\"105 2\",\"pages\":\"Pages 147-154\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1993-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/0742-8413(93)90186-O\",\"citationCount\":\"9\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative biochemistry and physiology. C: Comparative pharmacology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/074284139390186O\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative biochemistry and physiology. C: Comparative pharmacology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/074284139390186O","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Steroid-induced transmitter plasticity in insect peptidergic neurons
1. Transmitter plasticity, the ability to alter transmitter expression, has been demonstrated in a wide range of neurons in the vertebrates and invertebrates.
2. One preparation where this issue has been investigated in detail is a set of four neurosecretory neurons in the tobacco hawkmoth Manduca sexta.
3. These neurons undergo a transmitter switch during the transition from caterpillar to moth.
4. In larvae these neurons, known as the lateral neurosecretory cells (LNCs), express CAP2, a myomodulatory neuropeptide involved in the neuroregulation of the activity of visceral muscles.
5. By the adult moth stage, however, the LNCs are no longer producing CAP2 and instead are expressing a different peptide, bursicon, which is involved in tanning of the cuticle at adult emergence.
6. Here I review the evidence for this transmitter switch and discuss its regulation by steroids.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
