再结合一天:LFA-1/ICAM-1相互作用作为治疗靶点

Clinical and applied immunology reviews Pub Date : 2006-05-01 DOI:10.1016/j.cair.2006.09.004

L. Zecchinon, T. Fett, P. Vanden Bergh, D. Desmecht

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引用次数: 9

摘要

淋巴细胞功能相关抗原-1 (LFA-1, CD11a/CD18， α l - β2)积极参与负责免疫系统正常功能的分子相互作用，但也与多种病因(遗传、细菌、病毒、肿瘤、过敏和自身免疫性)的几种疾病有关。通过这种方式，淋巴细胞功能相关抗原-1与其主要配体细胞间粘附分子-1 (ICAM-1或CD54)之间的相互作用得到了广泛的研究，导致了治疗性抗体、多肽和小抑制分子的发展。

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Bind another day: The LFA-1/ICAM-1 interaction as therapeutic target

Lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18, α_Lβ₂) actively contributes to the molecular interactions responsible for normal functions of the immune system but is also associated to several diseases from various etiology (genetic, bacterial, viral, neoplastic, allergic, and autoimmune). In this way, the interaction between lymphocyte function-associated antigen-1 and its major ligand intercellular adhesion molecule-1 (ICAM-1 or CD54) has been extensively studied, leading to the development of therapeutic antibodies, peptides, and small inhibitory molecules.

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Clinical and applied immunology reviews

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