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生长激素释放激素试验对矮个子儿童的诊断价值。

Acta paediatrica Scandinavica. Supplement Pub Date : 1989-01-01 DOI:10.1111/j.1651-2227.1989.tb17176.x
O Butenandt
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引用次数: 14

摘要

生长激素释放激素(GHRH)测试应用于230多名儿童。61例生长激素(GH)缺乏症患者中有25例对GHRH有反应，GH增加大于10 ng/ml。在大多数特发性生长激素缺乏症患者中，使用每日注射GHRH的启动程序可以改善对GHRH的分泌反应。几乎所有家族性身材矮小的儿童都表现出生长激素水平的迅速增加，平均峰值水平为34.9 ng/ml(范围0.5- 144ng /ml)。第二次测试是在五名家族性身材矮小的儿童中进行的，因为他们对第一次测试没有反应。先天性生长发育迟缓儿童的生长激素反应与家族性身材矮小患者的生长激素反应没有差别。10名患有乌尔里希-特纳综合征的女孩的GH平均升高22 ng/ml(范围10.1-34.0 ng/ml)。糖皮质激素治疗，以及内源性皮质醇的高分泌，抑制垂体对GHRH的反应。在8名肥胖儿童的类固醇抑制试验中，单剂量地塞米松也观察到抑制。脑垂体反应性低也见于地中海贫血和输血诱导的血色素沉着症患者。这是结论，它是不可能检测GH缺乏与单一的GHRH试验。全面的内分泌学评估是证实诊断的必要条件。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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Diagnostic value of growth hormone-releasing hormone tests in short children.
Butenandt O. (Department of Paediatric Endocrinology, Children's Hospital, University of Munich, Munich, West Germany). Diagnostic value of growth hormone‐releasing hormone tests in short children. Acta Paediatr Scand [Suppl] 349 93, 1989.
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Acta paediatrica Scandinavica. Supplement
Acta paediatrica Scandinavica. Supplement
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