[肿瘤药物对老年患者的副作用]。

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
THERAPEUTISCHE UMSCHAU Pub Date : 2023-10-01
Vérène Dougoud-Chauvin
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引用次数: 0

摘要

导读:癌症是一种老年疾病,大约50%的新癌症病例发生在65岁及以上的人群中,预计到2030年这一数字将上升到58%。化疗仍然是癌症治疗的标准部分,同时还有免疫治疗和靶向治疗等新疗法。然而,与年轻人相比,老年患者化疗引起的毒性风险增加。在老年患者的肿瘤治疗中,必须考虑到各种药理学参数。在计划化疗时,用老年评估评估影响耐受性的年龄相关条件非常重要。几项研究表明,老年评估变量可用于识别化疗严重毒性风险最大的老年人。口腔肿瘤治疗有几个优点。然而,它们也有缺点,特别是在老年患者中,这可能导致效率较低或更早停止治疗。尽管存在免疫衰老和炎症的生理现象,但主要来自荟萃分析的亚组分析的数据倾向于表明,即使在老年患者中,免疫治疗也是有效且耐受性良好的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Side effects of oncology drugs in elderly patients].

Introduction: Cancer is a disease of old age with approximately 50% of new cancer cases occurring in humans aged 65 years and older and this number is expected to rise to 58% by 2030. Chemotherapy remains a standard part of cancer treatment, alongside new therapies such as immunotherapy and targeted therapies. However, older patients are at increased risk of chemotherapy-induced toxicity compared to younger adults. Various pharmacological parameters must be taken into account in the oncological treatment of older patients. Assessing age-related conditions that affect tolerability with geriatric evaluation is very important when planning chemotherapy. Several studies have shown that geriatric assessment variables can be used to identify older adults who are most at risk of severe toxicity from chemotherapy. Oral oncological therapies present several advantages. However, they also contain disadvantages, especially in older patients, which can lead to poorer efficiency or earlier discontinuation of therapy. Despite the physiological phenomena of immunosenescence and inflammaging, the data, mainly coming from subgroup analysis of meta-analyses, tends to show that immunotherapy is effective and well-tolerated even in older patients.

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来源期刊
THERAPEUTISCHE UMSCHAU
THERAPEUTISCHE UMSCHAU MEDICINE, GENERAL & INTERNAL-
CiteScore
0.50
自引率
0.00%
发文量
75
期刊介绍: Monat für Monat ein aktuelles Thema der praktischen Medizin - als Sammlung ein hochaktuelles Nachschlagewerk.
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