伤疤。

IF 76.9 1区 医学 Q1 MEDICINE, GENERAL & INTERNAL
Marc G Jeschke, Fiona M Wood, Esther Middelkoop, Ardeshir Bayat, Luc Teot, Rei Ogawa, Gerd G Gauglitz
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引用次数: 0

摘要

伤口愈合是对表皮和真皮层破坏的反应。这是一个复杂而精心安排的反应,目的是恢复皮肤的完整性和功能。然而,在数亿患者中,皮肤伤口愈合导致异常瘢痕形成,包括瘢痕疙瘩病变或增生性瘢痕形成。尽管肥厚性疤痕和瘢痕疙瘩的潜在机制尚不明确,但有证据表明,在易感个体中,细胞外基质的变化会因持续的炎症而持续存在,从而导致纤维化表型。随着过多的紊乱胶原蛋白的持续沉积,病变随之形成。异常疤痕不仅会使人虚弱和痛苦,还会导致功能障碍和外观的深刻变化,从而严重影响患者的生活。尽管对患者健康和医疗社会的巨大需求,但在异常疤痕患者的护理方面进展甚微。为了改善病理性瘢痕的预后,需要标准化和创新的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Scars.

Scars.

Wound healing occurs as a response to disruption of the epidermis and dermis. It is an intricate and well-orchestrated response with the goal to restore skin integrity and function. However, in hundreds of millions of patients, skin wound healing results in abnormal scarring, including keloid lesions or hypertrophic scarring. Although the underlying mechanisms of hypertrophic scars and keloid lesions are not well defined, evidence suggests that the changes in the extracellular matrix are perpetuated by ongoing inflammation in susceptible individuals, resulting in a fibrotic phenotype. The lesions then become established, with ongoing deposition of excess disordered collagen. Not only can abnormal scarring be debilitating and painful, it can also cause functional impairment and profound changes in appearance, thereby substantially affecting patients' lives. Despite the vast demand on patient health and the medical society, very little progress has been made in the care of patients with abnormal scarring. To improve the outcome of pathological scarring, standardized and innovative approaches are required.

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来源期刊
Nature Reviews Disease Primers
Nature Reviews Disease Primers Medicine-General Medicine
CiteScore
76.70
自引率
0.20%
发文量
75
期刊介绍: Nature Reviews Disease Primers, a part of the Nature Reviews journal portfolio, features sections on epidemiology, mechanisms, diagnosis, management, and patient quality of life. The editorial team commissions top researchers — comprising basic scientists and clinical researchers — to write the Primers, which are designed for use by early career researchers, medical students and principal investigators. Each Primer concludes with an Outlook section, highlighting future research directions. Covered medical specialties include Cardiology, Dermatology, Ear, Nose and Throat, Emergency Medicine, Endocrinology, Gastroenterology, Genetic Conditions, Gynaecology and Obstetrics, Hepatology, Haematology, Infectious Diseases, Maxillofacial and Oral Medicine, Nephrology, Neurology, Nutrition, Oncology, Ophthalmology, Orthopaedics, Psychiatry, Respiratory Medicine, Rheumatology, Sleep Medicine, and Urology.
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