氯霉素基配体促进苯乙炔与醛的不对称反应的研究。

IF 2.8 4区化学 Q2 CHEMISTRY, ANALYTICAL

Chirality Pub Date : 2023-11-16 DOI:10.1002/chir.23631

Baozhao Lu, Ruifeng Zhang, Congdi Chen, Liming Jin, Jiaqi Xu, Hongjun Yang

引用次数: 0

摘要

以氯霉素碱为原料合成了一系列手性配体。将这些配体应用于末端炔与醛的不对称催化反应中，得到了收率高(80-94%)、对映选择性高(82-96%)的丙炔醇产品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Research on promoting the asymmetric reaction of phenylacetylene with aldehydes by chloramphenicol base ligands

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Research on promoting the asymmetric reaction of phenylacetylene with aldehydes by chloramphenicol base ligands

A series of chiral ligands were synthesized using chloramphenicol base as starting materials. These ligands were applied to the asymmetric catalytic reactions of terminal alkynes with aldehydes to obtain a propargyl alcohol product in high yield (80–94%) with excellent enantioselectivities (82–96%).

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来源期刊

Chirality 医学-分析化学

CiteScore

4.40

自引率

5.00%

发文量

124

审稿时长

1 months

期刊介绍： The main aim of the journal is to publish original contributions of scientific work on the role of chirality in chemistry and biochemistry in respect to biological, chemical, materials, pharmacological, spectroscopic and physical properties. Papers on the chemistry (physiochemical, preparative synthetic, and analytical), physics, pharmacology, clinical pharmacology, toxicology, and other biological aspects of chiral molecules will be published.