[钙通道阻滞剂对离体大鼠十二指肠自发性收缩频率、幅度及对乙酰胆碱反应的影响]

Ankara Universitesi Dis Hekimligi Fakultesi dergisi = The Journal of the Dental Faculty of Ankara University Pub Date : 1989-09-01

E Koç, O Timlioğlu

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引用次数: 0

摘要

本文研究了钙通道阻滞剂对大鼠离体十二指肠自发性收缩频率、幅度及对乙酰胆碱反应的影响。维拉帕米、地尔硫卓和硝苯地平作为钙通道阻滞剂。所有阻滞剂均显著降低了频率。维拉帕米、地尔硫卓、硝苯地平三者的疗效比较，差异无统计学意义。硝苯地平、地尔硫卓和维拉帕米通过阻断钙离子的流入而显著降低自发性收缩的幅度。另一方面，与对照组相比，他们显著降低了对乙酰胆碱的反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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[The effects of calcium channel blockers on the frequency and amplitude of the spontaneous contractions and the responses to acetylcholine on isolated rat duodenum].

The effects of calcium channel blockers on the frequency, amplitude of the spontaneous contractions and responses to acetylcholine are investigated in isolated duodenum of rat. Verapamil, diltiazem and nifedipine were used as calcium channel blockers. All the blockers decreased the frequency significantly. When the effects of verapamil, diltiazem and nifedipine were compared with each other, significant difference was not found. Nifedipine, diltiazem and verapamil significantly reduced the amplitude of spontaneous contraction by blocking the influx of calcium ions. On the other hand, they reduced the responses to acetylcholine significantly, comparing with control groups.

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Ankara Universitesi Dis Hekimligi Fakultesi dergisi = The Journal of the Dental Faculty of Ankara University

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