中东呼吸综合征冠状病毒传播的预测建模与控制策略

Bibi Fatima, Mehmet Yavuz, Mati ur Rahman, Ali Althobaiti, Saad Althobaiti
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摘要

中东呼吸综合征冠状病毒(MERS-CoV)是一种高度传染性的呼吸道疾病,对公共卫生构成重大威胁。了解MERS-CoV的传播动态对于制定有效的控制和预防策略至关重要。在这项研究中,我们建立了一个精确的数学模型来捕捉MERS-CoV的传播动力学。我们纳入了一些与出生率和死亡率有关的新参数,这些参数是影响病毒传播的重要因素。我们从可靠来源获得流行病学数据来估计模型参数。我们计算它的基本复制数(R0)。稳定性理论用于分析模型的局部和全局性质,提供了对系统平衡状态及其稳定性的见解。通过灵敏度分析,找出影响传动动力学的最关键参数。我们的发现揭示了中东呼吸综合征冠状病毒传播动力学的重要见解。稳定性分析表明存在稳定平衡点,表明疫情的长期行为。通过对最优控制策略的评估,我们确定了有效的干预措施,以减轻MERS-CoV的传播。我们的模拟证明了时间相关控制变量(如支持性护理和治疗)在减少感染人数和控制疫情方面的影响。该模型可作为公共卫生当局设计有效控制和预防战略的宝贵工具,最终减轻中东呼吸综合征冠状病毒对全球卫生的负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predictive Modeling and Control Strategies for the Transmission of Middle East Respiratory Syndrome Coronavirus
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly infectious respiratory illness that poses a significant threat to public health. Understanding the transmission dynamics of MERS-CoV is crucial for effective control and prevention strategies. In this study, we develop a precise mathematical model to capture the transmission dynamics of MERS-CoV. We incorporate some novel parameters related to birth and mortality rates, which are essential factors influencing the spread of the virus. We obtain epidemiological data from reliable sources to estimate the model parameters. We compute its basic reproduction number (R0). Stability theory is employed to analyze the local and global properties of the model, providing insights into the system’s equilibrium states and their stability. Sensitivity analysis is conducted to identify the most critical parameter affecting the transmission dynamics. Our findings revealed important insights into the transmission dynamics of MERS-CoV. The stability analysis demonstrated the existence of stable equilibrium points, indicating the long-term behavior of the epidemic. Through the evaluation of optimal control strategies, we identify effective intervention measures to mitigate the spread of MERS-CoV. Our simulations demonstrate the impact of time-dependent control variables, such as supportive care and treatment, in reducing the number of infected individuals and controlling the epidemic. The model can serve as a valuable tool for public health authorities in designing effective control and prevention strategies, ultimately reducing the burden of MERS-CoV on global health.
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