在运动人群中,肝活检评估的nafld分期与肌肉减少症的诊断标准之间没有相关性:一项横断面研究

Luis Fernando Ferreira, Kally Janaina Berleze, André Ferreira D´Ávila, Cristiane Valle Tovo, Luis Henrique Telles Da Rosa
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引用次数: 0

摘要

目的:探讨运动人群中肌少症诊断标准与肝活检评估的非酒精性脂肪性肝病(NAFLD)水平的相关性。方法:横断面研究。年龄18岁,经肝活检证实为NAFLD,体力活动。骨骼肌减少症评估遵循EWGSOP2:握力测量肌肉力量,生物阻抗测量骨骼肌质量,正常步速测量身体表现。统计分析:为了检验连续变量组间的差异,对独立样本采用Student's T或Mann-Whitney U检验。相关性采用Pearson和Spearman检验。5%的显著性被认为(p<0.05)。结果:纳入52例NAFLD患者,其中女性35例,男性15例。在年龄或人体测量变量上没有差异。我们发现血小板(女性较高)、基础胰岛素、HOMA-IR和Quick(男性较高)的差异具有统计学意义。在肌肉减少症中,男性的握力表现出不同的优势。骨骼肌减少症与NAFLD水平之间无统计学意义的相关性。讨论:据报道,肌少症是NAFLD及其进展的独立危险因素。体育锻炼是治疗这两种疾病的最推荐和最有效的方法之一,因此预计不久坐的人可以降低这两项指标。然而,对于最好的方法并没有达成共识。此外,这两种疾病在诊断、预后、发病原因和危险因素方面具有异质性。结论:对于大多数人进行体育锻炼的人群,不可能发现肌肉减少症的诊断标准与NAFLD的分期之间的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
THERE IS NO CORRELATION BETWEEN STAGES OF NAFLD ASSESSED BY LIVER BIOPSY AND THE DIAGNOSTIC CRITERIA FOR SARCOPENIA IN ACTIVE POPULATIONS: A CROSS-SECTIONAL STUDY
Objective: To demonstrate the correlations of the diagnostic criteria for sarcopenia and the levels of Non-alcoholic Fat Liver Disease (NAFLD) assessed by liver biopsy in a physically active population. Methods: Cross-sectional study. Individuals aged >18 years, with NAFLD confirmed by liver biopsy, physically active. Sarcopenia assessment followed EWGSOP2: muscle strength by handgrip, Skeletal Muscle Mass by Bioimpedance, and physical performance by usual gait speed. Statistical Analysis: To test differences between groups in continuous variables, Student's T or Mann-Whitney U Test for independent samples. Pearson and Spearman tests were used for correlations. A 5% significance was considered (p<0.05). Results: 52 patients with NAFLD included, consisting of 35 women and 15 men. There was no difference in age or anthropometric variables. Were found difference statically significant in platelets (higher in women), basal insulin, HOMA-IR and Quick (higher in men). In sarcopenia, the handgrip strength showed difference in favors of men. There was no statistically significant correlation between the sarcopenia and NAFLD levels. Discussion: sarcopenia has been reported as an independent risk factor for NAFLD and its progressions. The physical exercise is one of the most recommended and more effective treatment for both conditions, so is expected that a non-sedentary individual can reduce both indicators. However, there is no consensus about the best method. Also, the both conditions share heterogeneity in diagnosis, prognosis, reason for develop and risk factors across the literature. Conclusion: For populations where most individuals are physically active, it is not possible to find correlation between sarcopenia diagnostic criteria and the stages of NAFLD.
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