儿童和成人隐孢子虫病:寄生虫学和临床流行病学特征。

L Lazăr, S Rădulescu
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引用次数: 0

摘要

采用隐孢子虫选择性诊断方法(改良Ziehl-Neelsen和Heine染色法),对481例急性或长期胃肠炎患者(儿童和成人)以及无症状患者(但具有专业、免疫或药理学感染风险)的粪便样本进行了研究。发现隐孢子虫阳性病例12例,即在所有调查流行病学人群(儿童、动物处理者、免疫缺陷患者、急性胃肠炎免疫功能正常的成人)中发现隐孢子虫感染的总患病率为2.48%。危险因素层次揭示了儿童群体在婴幼儿隐孢子虫病中感染寄生虫的作用,而成人隐孢子虫病的机会性和人畜共患性特征尤为明显。根据患者的免疫状态评估隐孢子虫病的演变,由于具有职业风险的免疫功能正常受试者出现卵囊排泄时间较长,因此不存在明显的临床差异。综述了隐孢子虫感染的不同临床流行病学和寄生虫学特征,强调了隐孢子虫方法学在当前诊断实践中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cryptosporidiosis in children and adults: parasitological and clinico-epidemiological features.

By using the elective diagnosis methodology for Cryptosporidium (modified Ziehl-Neelsen and Heine stainings), 481 faeces samples from patients--children and adults--presenting acute or prolonged gastroenteritis and also from asymptomatic ones, but with professional, immunological or pharmacological risk for infection, were studied. Twelve Cryptosporidium positive cases were identified, meaning a general prevalence of 2.48% Cryptosporidium infection was detected in all investigated epidemiological groups: children, animal handlers, immunodeficient patients, immunocompetent adults with acute gastroenteritis. The risk factors hierarchy elicited the role of children collectivities attending, for acquiring the parasite in infantile cryptosporidiosis, while the opportunistic and zoonotic feature of the disease was especially present in adults' cryptosporidiosis. The assessment of cryptosporidiosis evolution, according to patients' immune status, has not allowed an obvious clinical discrepancy, since the immunocompetent subjects with professional risk had presented a prolonged oocysts excretion. The different clinico-epidemiological and parasitological features of Cryptosporidium infection are commented and the importance of applying Cryptosporidium methodology in current diagnosis practice is emphasized.

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