花生皮肤超声提取物的抗氧化和抗癌活性

IF 1 4区农林科学 Q4 CHEMISTRY, APPLIED

Grasas y Aceites Pub Date : 2023-10-10 DOI:10.3989/gya.0990221

K.S.M. Hammad, A.M. El-Roby, S.M. Galal

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引用次数: 0

摘要

研究了超声辅助提取对花生皮中多酚类物质提取率及其抗氧化、抗癌活性的影响。超声强度为5.8 ~ 15.4 w/ cm2，料液比分别为1:20和1:30 (w/v)，提取时间为10、20、30、40 min。其多酚含量最高，为167.46 mg GAE/g，含量最高的是儿茶素、丁香酸和香草酸。PS超声提取物(PSUE)使葵花籽油的氧化稳定性提高到初始水平的4倍。PSUE对MCF-7、HepG-2、HCT-116、PC-3等癌细胞均有较高的抑制活性，IC50范围为1.85±0.13 ~ 6.1±0.43 μg/ml。此外，采用MTT法检测PSUE对HFB4人正常黑素细胞的细胞毒性。这些结果表明，PSUE可以作为天然的抗氧化剂和抗癌剂。

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Antioxidant and anticancer activities of peanut (Arachis hypogaea L.) skin ultrasound extract

This study evaluates the effect of ultrasound-assisted extraction on the extractability of polyphenols from peanut skins (PS) and their antioxidant, and anticancer activities. The extraction was performed with solid/solvent ratios of 1:20 and 1:30 (w/v) at ultrasound intensity ranging from 5.8 to 15.4 W/cm2 for different extraction times (10, 20, 30 and 40 min). The highest polyphenol yield was 167.46 mg GAE/g dried PS. The most abundant polyphenols were catechin, syringic acid, and vanillic acid. The PS ultrasound extract (PSUE) increased the oxidative stability of sunflower oil by four times its initial level. PSUE possessed high inhibitory activity against MCF-7, HepG-2, HCT-116, and PC-3 cancer cell lines, with IC50 ranging from 1.85 ± 0.13 to 6.1 ± 0.43 μg/ml. In addition, the cytotoxicity of PSUE was examined on HFB4 human normal melanocytes using the MTT assay. These results suggest that PSUE can be used as a natural antioxidant and anticancer agent.

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来源期刊

Grasas y Aceites 工程技术-食品科技

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Grasas y Aceites is a peer-reviewed journal devoted to the publication of original articles concerning the broad field of lipids, especially edible fats and oils from different origins, including non acyl lipids from microbial origin relevant to the food industry. It publishes full research articles, research notes, reviews as well as information on references, patents, and books. Grasas y Aceites publishes original articles on basic or practical research, as well as review articles on lipid related topics in food science and technology, biology, (bio)chemistry, medical science, nutrition, (bio)technology, processing and engineering. Topics at the interface of basic research and applications are encouraged. Manuscripts related to by-products from the oil industry and the handling and treatment of the wastewaters are also welcomed. Topics of special interest to Grasas y Aceites are: -Lipid analysis, including sensory analysis -Oleochemistry, including lipase modified lipids -Biochemistry and molecular biology of lipids, including genetically modified oil crops and micro-organisms -Lipids in health and disease, including functional foods and clinical studies -Technical aspects of oil extraction and refining -Processing and storage of oleaginous fruit, especially olive pickling -Agricultural practices in oil crops, when affecting oil yield or quality