ADAR1通过miR-122/BCL2A1信号抑制巨噬细胞凋亡并减轻脓毒症诱导的肝损伤

IF 3.1 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Journal of Clinical and Translational Hepatology Pub Date : 2023-11-13 DOI:10.14218/jcth.2023.00171

Shanshou Liu, Jiangang Xie, Chujun Duan, Xiaojun Zhao, Zhusheng Feng, Zheng Dai, Xu Luo, Yu Li, Minghe Yang, Ran Zhuang, Junjie Li, Wen Yin

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引用次数: 0

摘要

背景与目的随着脓毒症的发展，免疫细胞凋亡在免疫抑制和器官衰竭的发病机制中起着调节作用。我们之前报道过腺苷脱氨酶作用于RNA-1 (ADAR1)可减少脓毒症期间肠道和脾脏的炎症损伤。然而，ADAR1在脓毒症肝损伤中的作用和机制尚不清楚。

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ADAR1 Inhibits Macrophage Apoptosis and Alleviates Sepsis-induced Liver Injury Through miR-122/BCL2A1 Signaling

Background and AimsAs sepsis progresses, immune cell apoptosis plays regulatory roles in the pathogenesis of immunosuppression and organ failure. We previously reported that adenosine deaminases acting on RNA-1 (ADAR1) reduced intestinal and splenic inflammatory damage during sepsis. However, the roles and mechanism of ADAR1 in sepsis-induced liver injury remain unclear.

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来源期刊

Journal of Clinical and Translational Hepatology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

6.40

自引率

2.80%

发文量

496