HRCT复合纤维化评分与IPF的临床和生理参数相关

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL
Nils Hoyer, Michael Brun Andersen, Lenne Collatz Laustrup, Saher Burhan Shaker
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引用次数: 0

摘要

很少有研究描述特发性肺纤维化(IPF)患者的放射学纤维化程度是否与疾病严重程度的其他指标相关。直接相关性可以证实,这些患者的临床和生理限制归因于纤维化的程度,而不是合并症,如肺气肿或主观因素。目的:评估视觉纤维化评分与肺功能、生活质量和症状之间的相关性。方法:从丹麦PFBIO队列中招募IPF患者。HRCT扫描由两名经验丰富的胸科放射科医生使用标准化表格进行评分,对患者数据、彼此评分和扫描时间不知情。网状程度、牵引性支气管扩张程度和蜂窝状程度合并为复合定量纤维化评分。呼吸困难在一份调查问卷中进行评估,分值从0到5。结果:66例患者纤维化评分与FVC (r=-0.35, p=0.005)、DLCO (r=-0.53, p= 0.001)、St. George呼吸问卷(r=0.46, p=0.002)、呼吸困难(r=0.51, p= 0.001)相关。合并或不合并肺气肿的患者无显著差异。结论:IPF的视觉纤维化评分与肺功能测试、生活质量和呼吸困难相关,进一步验证了这些测量与肺纤维化程度直接相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
HRCT composite fibrosis score correlates with clinical and physiological parameters in IPF
Introduction: Few studies describe whether the extent of radiologic fibrosis correlates with other measures of disease severity in patients with idiopathic pulmonary fibrosis (IPF). A direct correlation could confirm that the clinical and physiological limitations in these patients are attributed to the extent of fibrosis, rather than co-morbidities, such as emphysema, or subjective factors. Objectives: To assess the correlation between a visual fibrosis score and lung function, quality of life and symptoms. Methods: Patients with IPF were recruited from the Danish PFBIO cohort. The HRCT scans were scored by two experienced thoracic radiologists using a standardized form and blinded to patient data, each-others scores and the time of scan. The extents of reticulation, traction bronchiectasis and honeycombing were combined in a composite quantitative fibrosis score. Dyspnoea was assessed in a questionnaire on a scale from 0 to 5. Results: In the 66 included patients, fibrosis score was correlated with FVC (r=-0.35, p=0.005), DLCO (r=-0.53, p<0.001), St. George’s Respiratory Questionnaire (r=0.46, p=0.002) and dyspnoea (r=0.51, p<0.001). There was no significant difference between patients with or without concomitant emphysema. Conclusions: A visual fibrosis score in IPF correlates with lung function tests, quality of life and dyspnoea, further validating these measurements as directly related to the extent of lung fibrosis.
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来源期刊
Imaging
Imaging MEDICINE, GENERAL & INTERNAL-
CiteScore
0.70
自引率
25.00%
发文量
6
审稿时长
7 weeks
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