{"title":"当代对口腔黏膜伤口愈合特点的看法:文献综述","authors":"Marjan Domysche, Iurii Mochalov","doi":"10.21272/eumj.2023;11(3):241-259","DOIUrl":null,"url":null,"abstract":"The purpose of the study is to update data on the features of oral mucosa (OM) wound healing through a systematic assessment of sources of scientific and medical information. Materials and Methods. An analysis of the data obtained during the information search in the online databases “PubMed”, “SciELO”, “Medscape”, and “Science of Ukraine: access to knowledge” was performed using the key words (tags): “mucous membrane of the oral cavity”, “oral mucosa”, “wounds of the mucous membrane”, “healing”, “regeneration”. Publications in periodical scientific issues, methodological recommendations, and reports were included in the list of sources of information. Results. According to the results of clinical observations, experimental studies on laboratory animals and volunteer patients, it was established that the healing of the OM wounds is qualitatively different from a similar process on the skin. This fact was established for both humans and animal models. Wound healing in the human body is a well-defined typical process aimed at restoring tissues after damage. Unlike the skin, OM wounds heal relatively quickly and with little or no scar tissue. And all this happens against the background of constant movement of soft tissues, stress (tension), mechanical abrasion, and contact with a large number of microorganisms in oral fluid. The leading factors of higher-quality regeneration of OM can be considered a moist wound healing environment, direct contact with the protective and regenerative systems of oral fluid which contains a high concentration of commensal microorganisms with immunomodulatory properties and more than 1000 protective and regulatory factors of saliva. There are distinct differences in the properties of the germ layer cells between the skin and OM and the cytokine profile of wound healing is also significantly different. Most reactions that take place in the main phases of the wound process in the oral cavity are faster and more intense. The processes of accumulation of collagen and elastin fibers, remodeling of the intercellular matrix (amorphous substance) are more qualitative. Conclusions: the data from the literature and the results of a significant number of studies allow us to state that faster wound closure, presence of saliva, faster immune response, increased release of anti-inflammatory cytokines, matrix metalloproteinase-mediated cleavage of chemokines, and remodeling of the extracellular matrix contribute to better wound healing and reduced scar formation on the OM, which, unfortunately, does not relate to the skin.","PeriodicalId":488652,"journal":{"name":"Shìdnoukraïnsʹkij medičnij žurnal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"CONTEMPORARY OPINIONS ON THE PECULIARITIES OF ORAL MUCOSA WOUNDS HEALING: A LITERATURE REVIEW\",\"authors\":\"Marjan Domysche, Iurii Mochalov\",\"doi\":\"10.21272/eumj.2023;11(3):241-259\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The purpose of the study is to update data on the features of oral mucosa (OM) wound healing through a systematic assessment of sources of scientific and medical information. Materials and Methods. An analysis of the data obtained during the information search in the online databases “PubMed”, “SciELO”, “Medscape”, and “Science of Ukraine: access to knowledge” was performed using the key words (tags): “mucous membrane of the oral cavity”, “oral mucosa”, “wounds of the mucous membrane”, “healing”, “regeneration”. Publications in periodical scientific issues, methodological recommendations, and reports were included in the list of sources of information. Results. According to the results of clinical observations, experimental studies on laboratory animals and volunteer patients, it was established that the healing of the OM wounds is qualitatively different from a similar process on the skin. This fact was established for both humans and animal models. Wound healing in the human body is a well-defined typical process aimed at restoring tissues after damage. Unlike the skin, OM wounds heal relatively quickly and with little or no scar tissue. And all this happens against the background of constant movement of soft tissues, stress (tension), mechanical abrasion, and contact with a large number of microorganisms in oral fluid. The leading factors of higher-quality regeneration of OM can be considered a moist wound healing environment, direct contact with the protective and regenerative systems of oral fluid which contains a high concentration of commensal microorganisms with immunomodulatory properties and more than 1000 protective and regulatory factors of saliva. There are distinct differences in the properties of the germ layer cells between the skin and OM and the cytokine profile of wound healing is also significantly different. Most reactions that take place in the main phases of the wound process in the oral cavity are faster and more intense. The processes of accumulation of collagen and elastin fibers, remodeling of the intercellular matrix (amorphous substance) are more qualitative. Conclusions: the data from the literature and the results of a significant number of studies allow us to state that faster wound closure, presence of saliva, faster immune response, increased release of anti-inflammatory cytokines, matrix metalloproteinase-mediated cleavage of chemokines, and remodeling of the extracellular matrix contribute to better wound healing and reduced scar formation on the OM, which, unfortunately, does not relate to the skin.\",\"PeriodicalId\":488652,\"journal\":{\"name\":\"Shìdnoukraïnsʹkij medičnij žurnal\",\"volume\":\"17 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Shìdnoukraïnsʹkij medičnij žurnal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.21272/eumj.2023;11(3):241-259\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Shìdnoukraïnsʹkij medičnij žurnal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.21272/eumj.2023;11(3):241-259","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
该研究的目的是通过对科学和医学信息来源的系统评估来更新口腔黏膜(OM)伤口愈合特征的数据。材料与方法。对在线数据库“PubMed”、“SciELO”、“Medscape”和“Science of Ukraine: access to knowledge”中的信息检索数据进行分析,关键词(标签)为:“口腔粘膜”、“口腔黏膜”、“粘膜伤口”、“愈合”、“再生”。期刊科学期刊、方法学建议和报告的出版物均列入信息来源清单。结果。根据临床观察,实验动物和志愿者患者的实验研究结果,确定OM伤口的愈合与皮肤上的类似过程有质的不同。这一事实在人类和动物模型中都得到了证实。人体伤口愈合是一个定义明确的典型过程,旨在恢复组织损伤后。与皮肤不同,OM伤口愈合相对较快,几乎没有疤痕组织。所有这些都是在软组织不断运动、应力(张力)、机械磨损以及与口液中大量微生物接触的背景下发生的。高质量OM再生的主导因素可以被认为是湿润的伤口愈合环境,直接接触口腔液的保护和再生系统,口腔液含有高浓度具有免疫调节特性的共生微生物和唾液的1000多种保护和调节因子。皮肤和OM的生殖层细胞特性有明显差异,伤口愈合的细胞因子谱也有显著差异。大多数反应发生在口腔伤口过程的主要阶段,速度更快,强度更大。胶原蛋白和弹性蛋白纤维的积累,细胞间基质(无定形物质)的重塑过程更定性。结论:文献数据和大量研究结果表明,伤口愈合更快、唾液的存在、免疫反应更快、抗炎细胞因子释放增加、基质金属蛋白酶介导的趋化因子分裂和细胞外基质重塑有助于伤口愈合更好,减少OM上的疤痕形成,不幸的是,这与皮肤无关。
CONTEMPORARY OPINIONS ON THE PECULIARITIES OF ORAL MUCOSA WOUNDS HEALING: A LITERATURE REVIEW
The purpose of the study is to update data on the features of oral mucosa (OM) wound healing through a systematic assessment of sources of scientific and medical information. Materials and Methods. An analysis of the data obtained during the information search in the online databases “PubMed”, “SciELO”, “Medscape”, and “Science of Ukraine: access to knowledge” was performed using the key words (tags): “mucous membrane of the oral cavity”, “oral mucosa”, “wounds of the mucous membrane”, “healing”, “regeneration”. Publications in periodical scientific issues, methodological recommendations, and reports were included in the list of sources of information. Results. According to the results of clinical observations, experimental studies on laboratory animals and volunteer patients, it was established that the healing of the OM wounds is qualitatively different from a similar process on the skin. This fact was established for both humans and animal models. Wound healing in the human body is a well-defined typical process aimed at restoring tissues after damage. Unlike the skin, OM wounds heal relatively quickly and with little or no scar tissue. And all this happens against the background of constant movement of soft tissues, stress (tension), mechanical abrasion, and contact with a large number of microorganisms in oral fluid. The leading factors of higher-quality regeneration of OM can be considered a moist wound healing environment, direct contact with the protective and regenerative systems of oral fluid which contains a high concentration of commensal microorganisms with immunomodulatory properties and more than 1000 protective and regulatory factors of saliva. There are distinct differences in the properties of the germ layer cells between the skin and OM and the cytokine profile of wound healing is also significantly different. Most reactions that take place in the main phases of the wound process in the oral cavity are faster and more intense. The processes of accumulation of collagen and elastin fibers, remodeling of the intercellular matrix (amorphous substance) are more qualitative. Conclusions: the data from the literature and the results of a significant number of studies allow us to state that faster wound closure, presence of saliva, faster immune response, increased release of anti-inflammatory cytokines, matrix metalloproteinase-mediated cleavage of chemokines, and remodeling of the extracellular matrix contribute to better wound healing and reduced scar formation on the OM, which, unfortunately, does not relate to the skin.