光动力疗法治疗外阴硬化萎缩性地衣

S. I. Surkichin, L. S. Kruglova, I. A. Apolikhina
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摘要

地衣硬化(LS)是一种慢性炎症性疾病,女性比男性多6-10倍。在一般人群中,每1000到300人中就有1人患有此病,但确切的患病率尚不清楚,因为这种疾病通常是无症状的。目的:评价PDT治疗LS患者与标准治疗方法的疗效。材料和方法:本研究纳入45例诊断为LS的患者,年龄45 ~ 72岁(中位年龄59岁)。根据所进行的治疗,将组分为亚组:1A组- LS患者给予外用糖皮质激素治疗,1B组- LS患者给予光动力治疗,1C组- LS患者给予外用糖皮质激素+ PDT联合治疗。结果:本研究开发了一种特殊的视觉模拟量表来评估外阴的客观状况。VAS包括以下参数:色素沉着、皮肤类型、肿胀(皮肤褶皱拉直时间)、裂缝或侵蚀的存在以及水分。根据所获得的数据,采用光动力治疗外阴硬化性地衣萎缩患者的综合治疗方法比药物治疗和单一pdt治疗的效果更高,这一点从VAS总指数的动力学上得到了证实:50.8%,而对照组分别为28.2%和35.1%,因此可以推荐在实际医疗中使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Photodynamic therapy in the treatment of vulvar lichen sclerosus et atrophicus
Lichen sclerosus (LS) is a chronic inflammatory disease that is 6–10 times more common in women than in men. LS affects between 1 in 1,000 and 1 in 300 people in the general population, but the exact prevalence is unknown since the disease is often asymptomatic. Objective: to evaluate the effectiveness of PDT in patients with LS in comparison with standard therapy methods. Material and methods: The study included 45 patients diagnosed with LS aged from 45 to 72 years (median age was 59 years). Depending on the therapy performed, the groups were divided into subgroups: Group 1A — patients with LS who were prescribed therapy with external glucocorticoids, Group 1B — patients with LS who were prescribed photodynamic therapy, Group 1C — patients with LS who were prescribed combined treatment: external glucocorticoids + PDT. Results: The study developed a special visual analogue scale to assess the objective condition of the vulva. VAS included the following parameters: pigmentation, skin pattern, turgor (skin fold straightening time), presence of cracks or erosions, and moisture. According to the data obtained, a complex treatment method using photodynamic therapy in patients with vulvar lichen sclerosus et atrophicus causes a higher effect than drug therapy and mono-PDT, which is confirmed by the dynamics of the total VAS index: 50.8 % compared with 28.2 % and 35.1 % in the comparison groups, respectively, therefore, it can be recommended for use in practical healthcare.
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