半凝集素-3:慢性心力衰竭左心室重构的独立心脏标志物

Q4 Biochemistry, Genetics and Molecular Biology
Mario Leesha Fernando, Santhi Silambanan
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摘要

简介和目的:心力衰竭(HF)是心脏泵血能力不能满足机体需求的一种危重疾病,发病率和死亡率均增高。它的发展是沉默的,因为缓慢的,渐进的重塑,后来才出现症状。脑钠肽(BNP)指示心室负荷状态,而不揭示其他机制,而一种新的标记物半乳糖凝集素-3 (Gal-3)提供心脏结构变化的信息,包括炎症、纤维化、重塑,以指导治疗。研究表明,在急性和慢性心力衰竭(CHF)患者中都存在凝集素- 3的上调。我们的研究目的是比较中度和重度LVD CHF患者的凝集素-3水平,并确定血清凝集素-3是否可以作为这类HF患者心室结构重构的独立心脏标志物。材料和方法:80例年龄在20 - 80岁之间,根据Framingham标准诊断为CHF,射血分数(EF)为45%,分为两组:(i)中度LVD和(ii)重度LVD。排除肾功能异常者。血清凝集素- 3与BNP比较;Gal- 3被确定为两类左室结构重塑的独立标志物。结果:重度LVD组HF患者半乳糖凝集素-3和BNP明显高于中度LVD组。多元线性回归显示,半乳糖凝集素-3是左室重构的独立预测因子,与左室舒张末期尺寸的变化有统计学意义,p < 0.001,而BNP无统计学意义。结论:重度左室功能不全患者Galectin -3和BNP水平高于中度左室功能不全患者,Galectin -3是慢性心力衰竭左室重构的独立心脏生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Galectin -3: an independent cardiac marker of left ventricular (LV) remodeling in chronic heart failure
Introduction and Aim: Heart failure (HF) with increased morbidity and mortality is a critical condition where the cardiac pumping capacity fails to meet up with the body’s demand. Its development is silent due to slow, progressive remodeling presenting with symptoms later. Brain Natriuretic peptides (BNP) denotes ventricular loading status which do not reveal other mechanisms whereas a novel marker Galectin-3 (Gal-3) provides information about cardiac structural changes which includes inflammation, fibrosis, remodeling for guiding treatment. Research studies demonstrated that there is upregulation of Galectin- 3 in both acute and chronic heart failure (CHF) individuals. The objectives of our study were to compare Galectin- 3 levels in moderate and severe LVD CHF patients and determine whether serum Galectin -3 can be used as an independent cardiac marker of ventricular structural remodeling in such HF individuals. Materials and Methods: 80 patients between 20 - 80 years diagnosed with CHF using Framingham criteria with ejection fraction (EF) of 45% and classified into two groups:(i) moderate LVD and (ii) severe LVD. Those with abnormal kidney functions were excluded. Comparison was done between serum Galectin - 3 and BNP; Gal- 3 was determined to be an independent marker of structural remodeling of LV between the two categories. Results: Galectin-3 and BNP were significantly increased in HF with severe LVD than moderate LVD. Multivariate linear regression showed Galectin-3 as an independent predictor of LV remodeling with respect to changes in LV end- diastolic dimension with statistically significant p 0.001 whereas BNP did not show any such significance. Conclusion: Galectin -3 and BNP levels were elevated in severe LV dysfunction than moderate LVD and concluded that Gal-3 is an independent cardiac biomarker of LV remodeling in Chronic heart failure.
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来源期刊
Biomedicine (India)
Biomedicine (India) Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
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