肥胖和正常体重伊拉克青年男性的瘦素、鸢尾素、催产素和胰岛素水平

Q4 Biochemistry, Genetics and Molecular Biology
Alaa Subhi Hammoud, Maryam I. Salman
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引用次数: 0

摘要

前言和目的:肥胖是一种严重的、危及生命的健康状况,在伊拉克和整个世界都很普遍。由于瘦素、鸢尾素、催产素和胰岛素被认为在能量消耗、葡萄糖稳态、调节体重、减少肥胖和提高预期寿命等方面起主要作用,因此本研究的目的是评估这些抗肥胖激素的浓度与胰岛素抵抗的关系。材料和方法:研究对象为100名平均年龄29.95岁的肥胖青年男性和50名平均年龄28.44岁的正常体重青年男性。结果:肥胖男性的平均瘦素浓度为24.08±9.91 ng/ml,明显高于正常体重男性的5.48 ng/ml。肥胖男性血清鸢尾素水平为8.9 ng/ml,正常体重男性血清鸢尾素水平为2.4 ng/ml,肥胖组血清鸢尾素水平明显高于正常体重组。肥胖组血清催产素平均浓度为6.41pg/ml,显著低于正常体重组29.55 pg/ml。肥胖者和正常体重者血清胰岛素水平分别为19.55±5.56和3.64微lU/ml,肥胖者明显高于正常体重者。肥胖男性的平均空腹血糖浓度为98.67mg/dl,明显高于正常体重(84±9.85 mg/ml)。肥胖男性的胰岛素抵抗(HOMA IR)显著高于正常体重男性(6.6)。结论:肥胖青年男性的血清瘦素、鸢尾素、胰岛素和胰岛素抵抗水平较高,而催产素水平明显较低。我们的研究还表明,肥胖会增加胰岛素抵抗的可能性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Levels of leptin, irisin, oxytocin and insulin in obese and normal weight Iraqi young men
Introduction and Aim: Obesity is a serious, life-threatening health condition that is prevalent in Iraq and the world as a whole. Since Leptin, irisin, oxytocin and insulin are proposed to play main roles in energy expenditure, glucose homeostasis, regulating body weight, reducing obesity and improving life expectancy so the aim of this study was to evaluate the concentrations of these anti-obesity hormones plus insulin resistance Materials and Methods: The study was conducted on 100 obese young men with a mean age of 29.95 years and fifty normal weight young men with a mean age of 28.44. Results: In obese men, the mean leptin concentration was 24.08±9.91 ng/ml which was significantly higher than in normal weight men 5.48 ng/ml. Serum irisin levels in obese men and normal weight were 8.9 ng/ml, 2.4 ng/ml respectively, and it was significantly higher in obese group in comparison to the normal weight group. The mean serum oxytocin concentration was significantly lower in obese group 6.41pg/ml in comparison to normal weight 29.55 pg/ml. Serum insulin levels in obese and normal weight were 19.55±5.56 and 3.64 micro lU/ml respectively and it was significantly higher in obese men. The mean fasting blood glucose concentration in obese men was 98.67mg/dl and it was significantly higher than in normal weight 84±9.85 mg/ml. Insulin resistance (HOMA IR) was significantly higher in obese men 6.6 than in normal weight 0.68. Conclusion: Serum levels of leptin, irisin, insulin, and insulin resistance are higher in obese young men, while oxytocin levels were noticeably low. Our study also shows that obesity increases the likelihood of insulin resistance.
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来源期刊
Biomedicine (India)
Biomedicine (India) Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)
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