{"title":"住院患者COVID-19病程严重程度与病毒载量的关系","authors":"M. V. Golodyaeva, E. V. Labintсeva","doi":"10.18705/2782-3806-2023-3-4-59-65","DOIUrl":null,"url":null,"abstract":"Clinical manifestations of COVID-19 vary in different patients from asymptomatic to severe multiple organ failure. The aim of this study was to analyze the severity of COVID-19 in hospitalized patients depending on the initial viral load of SARS-CoV-2. Study included 156 patients 18 years old and more. In the RT-PCR test, viral load was assessed by amplification cycle threshold Ct. The result was considered positive for Ct values < 40 and negative for Ct ≥ 40. 3 groups of 52 people each with different trajectories of the course of the disease were identified: 1 — mild, 2 — moderate, 3 — severe/fatal. The values of the median Ct cycle threshold upon admission of patients in group 3 to the hospital were significantly lower, indicating higher initial levels of viral RNA in patients with more severe disease. This pattern persisted over a 28-day period, and it was in this 3 group that higher levels of viral RNA were detected throughout the time compared to other disease trajectories. In conclusion, the effect of the initial SARS-CoV-2 viral load and its dynamics during hospitalization on the severity of COVID-19 is shown. This parameter can be a prognostic marker for assessing the clinical condition of patients during treatment.","PeriodicalId":499018,"journal":{"name":"Russian Journal for Personalized Medicine","volume":"25 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dependence of the severity of the course of COVID-19 on viral load in hospitalized patients\",\"authors\":\"M. V. Golodyaeva, E. V. Labintсeva\",\"doi\":\"10.18705/2782-3806-2023-3-4-59-65\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Clinical manifestations of COVID-19 vary in different patients from asymptomatic to severe multiple organ failure. The aim of this study was to analyze the severity of COVID-19 in hospitalized patients depending on the initial viral load of SARS-CoV-2. Study included 156 patients 18 years old and more. In the RT-PCR test, viral load was assessed by amplification cycle threshold Ct. The result was considered positive for Ct values < 40 and negative for Ct ≥ 40. 3 groups of 52 people each with different trajectories of the course of the disease were identified: 1 — mild, 2 — moderate, 3 — severe/fatal. The values of the median Ct cycle threshold upon admission of patients in group 3 to the hospital were significantly lower, indicating higher initial levels of viral RNA in patients with more severe disease. This pattern persisted over a 28-day period, and it was in this 3 group that higher levels of viral RNA were detected throughout the time compared to other disease trajectories. In conclusion, the effect of the initial SARS-CoV-2 viral load and its dynamics during hospitalization on the severity of COVID-19 is shown. This parameter can be a prognostic marker for assessing the clinical condition of patients during treatment.\",\"PeriodicalId\":499018,\"journal\":{\"name\":\"Russian Journal for Personalized Medicine\",\"volume\":\"25 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-09-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal for Personalized Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18705/2782-3806-2023-3-4-59-65\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal for Personalized Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18705/2782-3806-2023-3-4-59-65","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Dependence of the severity of the course of COVID-19 on viral load in hospitalized patients
Clinical manifestations of COVID-19 vary in different patients from asymptomatic to severe multiple organ failure. The aim of this study was to analyze the severity of COVID-19 in hospitalized patients depending on the initial viral load of SARS-CoV-2. Study included 156 patients 18 years old and more. In the RT-PCR test, viral load was assessed by amplification cycle threshold Ct. The result was considered positive for Ct values < 40 and negative for Ct ≥ 40. 3 groups of 52 people each with different trajectories of the course of the disease were identified: 1 — mild, 2 — moderate, 3 — severe/fatal. The values of the median Ct cycle threshold upon admission of patients in group 3 to the hospital were significantly lower, indicating higher initial levels of viral RNA in patients with more severe disease. This pattern persisted over a 28-day period, and it was in this 3 group that higher levels of viral RNA were detected throughout the time compared to other disease trajectories. In conclusion, the effect of the initial SARS-CoV-2 viral load and its dynamics during hospitalization on the severity of COVID-19 is shown. This parameter can be a prognostic marker for assessing the clinical condition of patients during treatment.