Tobias Kratz, Jan Dauvergne, Anne-Sophie Kronberg, David Katzer, Rainer Ganschow, Marit Bernhardt, Sarah Westeppe, Benjamin Bierbach, Joanna Strohm, Christina Oetzmann von Sochaczewski
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引用次数: 0
摘要
生物力学在胃肠病学教育模型的创建和描述内窥镜检查时穿孔中空器官的必要力量方面取得了进展。因此,我们研究了猪肠段的断裂力,以及它们是否可以根据体重或冠臀长来预测。根据先验功率分析,共纳入10头猪。断裂力由机动试验台测定。我们发现肠段断裂力不同(H(6) = 33.7, p <0.0001):回肠破肠力(x¯= 24.14 N)高于空肠(x¯= 14.24 N, p = 0.0082)和结肠(x¯= 11.33 N, p <0.0001)断裂力。后者也小于盲肠断裂力(x¯= 24.6 N, p = 0.0044)。同样,直肠(x¯= 23.57 N)破断力高于空肠(p = 0.0455)和结肠(p = 0.0006)破断力。断裂力与体重或冠臀长度无关(R <0.49, p >0.148)。肠段的断裂力不同。结肠对牵引力的阻力最小。为了验证内窥镜检查和手术的猪模型,人类是否存在类似的关系仍有待确定。
Not All Porcine Intestinal Segments Are Equal in Terms of Breaking Force, but None Were Associated to Allometric Parameters
Biomechanics are gaining ground in gastroenterology in the creation of educational models and to describe the necessary forces to perforate hallow organs during endoscopy. We thus investigated the breaking forces of porcine intestinal segments and whether they could be predicted based on body weight or crown–rump length. Based on a priori power-analyses, 10 pigs were included. The breaking forces were determined with a motorized test stand. We found that the breaking forces of intestinal segments were different (H(6) = 33.7, p < 0.0001): Ileal breaking force (x¯ = 24.14 N) was higher than jejunal (x¯ = 14.24 N, p = 0.0082) and colonic (x¯ = 11.33 N, p < 0.0001) breaking force. The latter was also smaller than cecal breaking force (x¯ = 24.6 N, p = 0.0044). Likewise, rectal (x¯ = 23.57 N) breaking force was higher than jejunal (p = 0.0455) and colonic (p = 0.0006) breaking force. Breaking forces were not correlated to body weight or crown–rump length (R < 0.49, p > 0.148). Intestinal segments differ in their breaking forces. The colon had the least resistance to traction forces. It remains to be determined if similar relationships exist in humans in order to validate porcine models for endoscopy and surgery.