CD1a的免疫表达和组织病理学在牛皮癣的病变和非病变皮肤:一个横断面研究

Kavitha Yelavath, CH Jyothi, T Divyagna, B Swapna Kumari
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摘要

银屑病是一种由t淋巴细胞和树突状细胞介导的长期自身免疫性疾病。朗格汉斯细胞是在表皮中发现的一种独特的树突状细胞,它们可以通过1a (CD1a)阳性的簇分化来识别。它们在牛皮癣的发病机制中起重要作用。目的:探讨CD1a免疫表达在银屑病早期诊断中的应用价值,探讨临床诊断的银屑病患者皮肤活检的病理组织学变化。材料和方法:2017年9月至2019年8月在印度特伦甘纳邦塞昆德拉巴德的甘地医院进行了一项横断面研究。对门诊(OPD)的50例银屑病患者进行皮肤活检。研究了早期银屑病的组织病理学特征,并分析了CD1a在病变、病变周围和远处皮肤中的免疫表达。使用社会科学统计软件包(SPSS)软件使用学生t检验对数据进行分析。结果:51 ~ 60岁15例,占30%;11 ~ 20岁10例,占20%。男性占多数(36例,72%)。大多数活检来自下肢(24例,48%),其次是背部(13例,26%)。本研究中,病变周围皮肤中CD1a阳性朗格汉斯细胞的平均数量(54.92±5.26)个高于病变皮肤(30±3.96)个,差异有统计学意义(p值=0.04)。结论:根据本研究的观察,在临床成熟的银屑病斑块出现之前,病灶周围皮肤CD1a的强烈阳性反应可用于诊断银屑病的早期临床阶段。早期诊断可能促使医生尽早开始治疗
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunoexpression of CD1a and Histopathology in Lesional and Non Lesional Skin in Psoriasis: A Cross-sectional Study
Introduction: Psoriasis is a long-lasting autoimmune disease mediated by T-lymphocytes and dendritic cells. Langerhans cells are a unique population of dendritic cells found in the epidermis, where they can be identified by Cluster of Differentiation 1a (CD1a) positivity. They play an important role in the pathogenesis of psoriasis. Aim: To evaluate the utility of immunoexpression of CD1a in the early diagnosis of psoriasis and to study the histopathology of skin biopsies from clinically diagnosed cases of psoriasis. Materials and Methods: A cross-sectional study was conducted from September 2017 to August 2019 at Gandhi Hospital, Secunderabad, Telangana, India. Skin biopsies were taken from 50 patients with psoriasis from the Outpatient Department (OPD). Histopathological features in early psoriasis were studied, and CD1a immunoexpression in lesional, perilesional, and distant skin was analysed. The data were analysed using Student’s t-test with the Statistical Package for the Social Sciences (SPSS) software. Results: Half of the cases were found in two age groups: 51-60 years (15 patients, 30%) and 11-20 years (10 patients, 20%). The majority of the cases were males (36 patients, 72%). Most of the biopsies were taken from the lower limb (24 patients, 48%), followed by the back (13 patients, 26%). In this study, the average number of CD1a positive Langerhans cells was highest (54.92±5.26) in perilesional skin compared to lesional skin (30±3.96), which was statistically significant (p-value=0.04). Conclusion: Based on the observations in this study, a strong positive reaction of CD1a in perilesional skin can be used to diagnose psoriasis in the early clinical stages, before full-blown clinical psoriatic plaques have appeared. Early diagnosis may prompt physicians to initiate treatment early
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