Novel patterns for drug synergistic mechanism research

Drug combination based on synergistic effect is commonly used in clinical practice, especially in the application of traditional medicine. Exploring the combination mechanism could help to better utilize this synergistic advantage. However, current research focuses more on the efficacy enhancing of drugs, while ignoring the toxicity reducing effects. Here, we established two drug synergy patterns based on the different situations of drugs and targets, in order to better illuminate the synergistic mechanism of drugs.