乌拉圭赫里福德牛的先天性毛少病(KRT71突变)

IF 0.8 4区 农林科学 Q3 VETERINARY SCIENCES
Agustín Romero-Benavente, Carolina Briano-Rodriguez, Fernando Dutra-Quintela
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引用次数: 0

摘要

摘要:先天性毛少病是乌拉圭赫里福德牛的一种重要疾病,在世界各地都有报道。然而,致病突变KRT71直到最近才被发现。本文描述了在两个商业农场的赫里福德小牛中观察到的krt71 -先天性毛少症的临床、组织病理学、毛谱学和遗传学结果。在1号农场检查了15头纯种投票HF牛群中出生的5头受感染的新生小牛,在2号农场检查了一头断奶小牛。从患病小牛和对照小牛、公牛和母牛身上采集皮肤活检进行组织病理学检查,毛发样本进行毛谱检查,血液样本进行基因分型。患病动物被毛为浅棕色,被毛稀疏、薄、卷曲或呈羊毛状。少毛性皮肤干燥、红斑、鳞片。毛谱分析显示毛发薄、碎片化、卷曲,有不规则的大黑素体群。主要的组织病理学发现包括明显的毛囊发育不良伴空泡形成,赫胥黎氏层内有异常大的毛透明蛋白颗粒,头发碎片、基质细胞和发育不良的毛囊中有多种黑色素聚集。无皮炎组织学病变。DNA分析证实,KRT71突变的少毛小牛为纯合子,而对照小牛、公牛和2号农场的奶牛为杂合子携带者。总之,由KRT71突变引起的赫里福德牛先天性毛少症是一种颜色稀释滤泡发育不良。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hypotrichosis congenita (KRT71 mutation) in Hereford cattle in Uruguay
ABSTRACT: Hypotrichosis congenita is a significant disease in Hereford cattle in Uruguay and has been reported worldwide. However, the causal mutation KRT71 has only been recently identified. This communication describes the clinical, histopathological, trichographic, and genetic findings of KRT71-hypotrichosis congenita observed in Hereford calves from two commercial farms. Five affected newborn calves, born in a herd of 15 purebred Polled HF cows, were examined in Farm 1, and one weaned calf in Farm 2. Skin biopsies for histopathology, hair samples for trichogram, and blood samples for genotyping were obtained from affected and control calves and the sire bull and mother cows. Affected animals exhibited a light brown coat with sparse, thin, curly or woolly haircoat. Hypotrichotic skin was dry, erythematous, and scaly. Trichogram analysis revealed thin, fragmented, curly hairs with irregular macro-melanosome groups. The main histopathological findings included marked follicular dysplasia with vacuolation, abnormally large trichohyaline granules in Huxley’s layer, and multiple melanin aggregates in hair fragments, matrix cells, and dysplastic follicles. There were no histological lesions of dermatitis. DNA analysis confirmed that hypotrichotic calves were homozygous for the KRT71 mutation, while one control calf, the bull, and cows in Farm 2 were heterozygous carriers. In conclusion, hypotrichosis congenita in Hereford cattle due to the KRT71 mutation is a color dilution follicular dysplasia.
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来源期刊
Pesquisa Veterinaria Brasileira
Pesquisa Veterinaria Brasileira 农林科学-兽医学
CiteScore
1.30
自引率
16.70%
发文量
41
审稿时长
9-18 weeks
期刊介绍: Pesquisa Veterinária Brasileira - Brazilian Journal of Veterinary Research (http://www.pvb.com.br), edited by the Brazilian College of Animal Pathology in partnership with the Brazilian Agricultural Research Organization (Embrapa) and in collaboration with other veterinary scientific associations, publishes original papers on animal diseases and related subjects. Critical review articles should be written in support of original investigation. The editors assume that papers submitted are not being considered for publication in other journals and do not contain material which has already been published. Submitted papers are peer reviewed. The abbreviated title of Pesquisa Veterinária Brasileira is Pesqui. Vet. Bras.
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