使用分布式参数系统的免疫过程多物理场建模

Pub Date : 2023-10-01 DOI:10.1515/rnam-2023-0021

Gennady A. Bocharov, Dmitry S. Grebennikov, Rostislav S. Savinkov

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引用次数: 0

摘要

免疫系统是一个由细胞组成的复杂的分布式系统，它们在机体内循环、交流和周转，以响应抗原干扰。我们讨论了模拟人类和实验动物免疫系统功能的新方法，重点关注其“复杂性”。本文回顾了新兴的数学和计算机模型，以描述免疫系统的多样性、细胞/细胞因子网络通信结构、等级调节和免疫库的进化动态。

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Multiphysics modelling of immune processes using distributed parameter systems

Abstract The immune system is a complex distributed system consisting of cells, which circulate through the body, communicate and turnover in response to antigenic perturbations. We discuss new approaches to modelling the functioning of the immune system of humans and experimental animals with a focus on its ‘complexity’. Emerging mathematical and computer models are reviewed to describe the immune system diversity, the cell/cytokine network communication structures, hierarchical regulation, and evolutionary dynamics of immune repertoires.

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