Outside Back Cover: Volume 4 Issue 3

Outside back cover image: On-skin devices that track multi-vital regional tissue hemodynamics are essential for the long-term monitoring of oxygen-mediated effects in patients with cardiovascular diseases. This study presents an ultrathin and ultralight near-infrared optoelectronic biosensor for continuous monitoring of regional tissue hemodynamics lesions caused by the peripheral arterial disease (PAD). The biosensor is capable of efficiently detecting multiple vital parameters and accurately evaluating changes in tissue hemodynamics of patients. The clinical experiments are highly correlated with the results of traditional diagnose methods, such as ankle brachial index (ABI) and computerized tomography angiography (CTA). We especially highlight the capability of the device to correct false positive results of ABI for patients with arteriosclerosis or low lesion planes. The proposed device compensates for the limitations of bulkiness and misdiagnosis in current clinical methods during the perioperational period. (DOI: https://doi.org/10.1002/smm2.1157)