肝细胞癌DNA修复基因特征和潜在分子亚型的鉴定

Open Journal of Clinical and Medical Case Reports Pub Date : 2023-03-10 DOI:10.52768/2379-1039/1991

Yutao Wang

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引用次数: 0

摘要

DNA修复是肿瘤进展的关键因素，因为它影响肿瘤突变负担、基因组稳定性、PD-L1表达、肿瘤浸润淋巴细胞(til)和免疫治疗反应。在这项研究中，我们构建了一个基于DNA损伤反应(DDR)相关基因的肝细胞癌(HCC)预后模型。

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Identification of DNA repair gene signature and potential molecular subtypes in hepatocellular carcinoma

DNA repair is a critical factor in tumor progression since it influences tumor mutational burden, genome stability, PD-L1 expression, tumor-infiltrating lymphocytes (TILs) and immunotherapy response. In this study, we constructed a prognostic model for hepatocellular carcinoma (HCC) based on DNA damage response (DDR)-related genes.

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Open Journal of Clinical and Medical Case Reports

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