新型配体N-[4-({2-[1-(吡啶-2-基)乙基]肼基碳硫基}氨基)苯基]乙酰胺铜(II)配合物的合成、表征及生物学性能

Roman Rusnac, Olga Garbuz, Yurii Chumakov, Victor Tsapkov, Christelle Hureau, Dorin Istrati, Aurelian Gulea
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引用次数: 0

摘要

首次合成了含扑热息痛结构单元的硫代氨基脲型配体。以铜(II)盐为基料,合成了5个新的配位化合物:[Cu(L)CH3COO](1)、[{Cu(L)Cl}2]·H2O(2)、[Cu(L)H2O·DMF]NO3(3)、[Cu(L)Br](4)、[Cu(L)H2O]ClO4(5),其中HL为N-[4-({2-[1-(吡啶-2-基)乙基]肼碳硫基}氨基)苯基]乙酰胺。用核磁共振、红外光谱、光谱学和x射线晶体学对新产物进行了表征。所有铜(II)配位化合物通过元素分析、FTIR、EPR光谱和摩尔电导率进行了表征。单晶x射线衍射分析表明了硫代氨基脲HL及其配合物1-3的结构。测定了所有化合物的抗菌、抗真菌和抗氧化活性,并研究了它们对大水蚤的毒性。生物学评价表明,大多数合成的化合物具有良好的抗菌、抗真菌和抗氧化活性。在许多情况下,它们的抗菌/抗真菌活性可与用于这些目的的某些药物相媲美,在某些情况下甚至超过它们。HL和配合物2-5的抗氧化活性优于Trolox。此外,HL和复合物2对D. magna几乎没有毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis, Characterization, and Biological Properties of the Copper(II) Complexes with Novel Ligand: N-[4-({2-[1-(pyridin-2-yl)ethylidene]hydrazinecarbothioyl}amino)phenyl]acetamide
For the first time, a thiosemicarbazone-type ligand containing a paracetamol structural unit was synthesized. Five new coordination compounds based on copper(II) salts: [Cu(L)CH3COO] (1), [{Cu(L)Cl}2]·H2O (2), [Cu(L)H2O·DMF]NO3 (3), [Cu(L)Br] (4), [Cu(L)H2O]ClO4 (5), were obtained, where HL is N-[4-({2-[1-(pyridin-2-yl)ethylidene]hydrazinecarbothioyl}amino)phenyl]acetamide. The new HL was characterized by NMR, FTIR, spectroscopy, and X-ray crystallography. All copper(II) coordination compounds were characterized by elemental analysis, FTIR, EPR spectroscopy, and molar electrical conductivity. Furthermore, single crystal X-ray diffraction analysis elucidated the structures of thiosemicarbazone HL as well as complexes 1–3. All compounds were tested for antimicrobial, antifungal, and antioxidant activities, and their toxicity to Daphnia magna was studied. Biological evaluation has revealed that most of the synthesized compounds demonstrate promising antibacterial, antifungal, and antioxidant activities. In many cases, their antibacterial/antifungal activity is comparable to that of certain drugs used in medicine for these purposes, and in some cases, even surpasses them. HL and complexes 2–5 exhibit antioxidant activity that surpasses that of Trolox. Furthermore, HL and complex 2 display virtually no toxicity to D. magna.
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